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AOC Minutes 25th September 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_25.09.20_redacted.pdf14 May 2024: These are not the usual brand and therefore would usually need a new face fit test. -
AOC Minutes 21st February 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_21.02.20_redacted.pdf14 May 2024: The AWERB committee will be reviewing the letter sent to the Vice Chancellor from PETA regarding the use of the Forced Swim Test. -
AOC minutes 17th November 2023
https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_171123_redacted.pdf14 May 2024: mice to test the principal. -
3Rs Minutes 7th July 2021 Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_070721_redacted.pdf14 May 2024: Are the surgical skills already present within the team? Behavioural tests. • -
AOC Minutes 25th November 2022
https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_251122_redacted_0.pdf14 May 2024: cage. had a meeting regarding the auto watering system and recent test results show that the new dosing? -
AOC Minutes 17th February 2023
https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_170223_redacted.pdf17 Jan 2024: had a discussion with who said that there is a device that can be fitted to a tap to test for Legionella automatically. -
AWERB Sub-Standing Committee Meeting Minutes - 12th June 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_120620_redacted.pdf7 Dec 2022: Specific refinements in regards to behavioural tests added to the Refinement section. • ... Further information in regards to specific tests planned. • Specific volumes need adding. -
AWERB Sub-Standing Committee Meeting Minutes - 10th August 2022
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_100822_redacted.pdf7 Dec 2022: Further information. around how the behavioral tests will be managed in regards to the rest time between each and if different types of tests used will be mixed. • ... the animals during your project?’ section. • The inclusion of limits and the -
AWERB Sub-Standing Committee Meeting Minutes - 12th September 2022
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_120922_redacted.pdf7 Dec 2022: Further information. around how the behavioral tests will be managed in regards to the rest time between each and if different types of tests used will be mixed. • ... the animals during your project?’ section. • The inclusion of limits and the -
AWERB Standing Committee Meeting Minutes - 29th January 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_290120_redacted_1.pdf7 Dec 2022: The removal of specific tests from Appendix and the inclusion of these as a separate step in. ... Protocols and • Further information included in Protocols and in regards to specific tests planned. • -
AWERB Operations Committee Redacted Minutes October 2019
https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_18.10.19_redacted.pdf11 Jan 2023: A FOI has been requested for a swimming test but we don’t currently have any happening at the so we were able to supply a nil response. -
AWERB Standing Committee Meeting Minutes - 18th December 2019
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_181219_redacted.pdf7 Dec 2022: informed the committee that the had received FOI requests about use and authorisation of the Porsolt Forced Swim Test. -
AWERB Standing Committee Meeting Minutes - 21st October 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_211020_redacted_0.pdf7 Dec 2022: Review the number of blood samples being taken during a Glucose Tolerance Test to ensure that the number is sufficient. • -
AWERB Standing Committee Meeting Minutes - 24th April 2019
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_240419_redacted.pdf7 Dec 2022: Frequencies of specific tests planned added to the Part D: Project Plan. -
AWERB Standing Committee Meeting Minutes - 27th October 2021
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_271021_redacted.pdf7 Dec 2022: could understand it. • The aim to test efficacy could be further clarified. • -
AWERB Sub-Standing Committee Minutes 14th June 2023
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_140623_redacted.pdf30 Aug 2023: c) Amendment: The committee discussed the following:. • Further detail required in the Project Harms section in regards to specific tests planned and the impact on the animals. • -
AWERB Sub-Standing Committee Meeting Minutes - 9th November 2022
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_091122_redacted.pdf7 Mar 2023: Further detail included in the Project Plan to explain why specific tests are the most appropriate. • -
AWERB Standing Committee Meeting Minutes - 29th April 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_290420_redacted_0.pdf7 Dec 2022: Further information in regards to specific tests planned in Protocol 7. • -
AWERB Sub-Standing Committee Meeting Minutes - 8th February 2021
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_080221_redacted.pdf7 Dec 2022: Page 2 of 3. • Suggest investigating whether the GTT test is as effective with the glucose administered by the more natural oral route and if so undertake a studu dosing by -
PPL number: | Granted: 06 Jan 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/support_procedures_for_neural_repair_nts_redacted.pdf19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds. -
AWERB Sub-Standing Committee Meeting Minutes - 10th January 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_100120_redacted_0.pdf7 Dec 2022: Further detail required around specific tests undertaken in Section 2.5. • -
PPL number: | Granted: 07 Aug 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/microglial_targets_in_brain_pathology_and_ageing_nts_redacted.pdf20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated -
PPL number: | Granted: 06 Aug 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/mice_with_transgenic_immunoglobulin_loci_nts_redacted.pdf20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models. -
Developing new mulivalent recombinant vaccines platforms against…
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines. -
PPL number: | Granted: 03 Jul 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/regeneration_in_the_nervous_system_nts_expires2024_redacted.pdf13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate, -
Development of novel therapeutics for pain (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_novel_therapeutics_for_pain_non-technical_summary_redacted.pdf30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans. -
Molecular mechanisms of tolerance and immunosuppression…
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in -
Development of nerve neuroprosthetic treatment
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients. -
The diversity of glia in health, development and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_diversity_of_glia_in_health_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes. -
Discovery and development of treatments for immunological diseases
https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to -
Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function. -
PPL number: | Granted: 17 Feb 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/roles_for_genomic_instability_in_cancer_and_ageing_redacted.pdf18 Jun 2021: Particular cells from animals can be used to test the effect of drugs that could stop a disease. ... Mice will be removed from test scenarios if suffering from an adverse stress reaction, or other unexpected adverse effects. -
Platelets as a therapeutic tool
https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease. -
Provision of an outsourced drug discovery platform for metabolic and…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary. -
Models of mitochondrial diseases, pathogenesis and therapy
https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf30 Apr 2024: The knowledge gained will be used to develop and test of novel therapeutic interventions. ... Live animals are required to test in vivo therapies. Wherever possible, animals will be killed prior to tissue harvest. -
Exploring Bioelectronic Approaches to Nervous System Restoration in…
https://www.ubs.admin.cam.ac.uk/system/files/public/exploring_bioelectronic_approaches_to_nervous_system_restoration_in_large_animals_non-technical_sum_redacted.pdf30 Apr 2024: These tests showed that the devices work well in recording nerve activity and helping to control how nerves work. ... For example, we do a lot of computer simulations, which helps us test fewer things in living animals. -
Profiling of test agents in rodents in a drug discovery platform
https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf30 Apr 2024: We will also study how the test agent distributes itself around the body. ... Dosing will usually be daily, but this may vary depending upon the test agent. -
Cartilage repair and replacement
https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf29 Apr 2024: 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals per test group at each time point). -
PPL number: | Granted: 01 Dec 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/radiation_combinations_for_cancer_treatment_nts_redacted.pdf19 Aug 2021: What's the aim of this project? To test anti-cancer agents in combination with ionising radiation with the aim of improving current clinical therapies. ... Animal studies are only performed after every feasible test has been conducted on cancer cells in -
PK and PKPD studies to support Respiratory and Immunology research
https://www.ubs.admin.cam.ac.uk/system/files/public/pk_and_pkpd_studies_to_support_respiratory_and_immunology_research_non-technical_summary_redacted.pdf30 Apr 2024: This licence will enable us to test new treatments in mice and rats and predict how much to use in these models. ... Pharmacokinetic studies are usually not hypothesis testing in a statistical sense, so we do not test for a significant difference in -
Provision of an outsourced drug development platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_development_platform_for_the_treatment_of_bleeding_disorders_non-te_redacted.pdf30 Apr 2024: The majority of the data will be collected at the end of studies, where animals will be under deep terminal anaesthesia, in order to perform tests on how effective a test ... Giving a drug before injury can test its effect on bleeding and clot formation. -
Control of equine herpesviruses in the horse
https://www.ubs.admin.cam.ac.uk/system/files/public/control_of_equine_herpesviruses_in_the_horse._non-technical_summary_redacted.pdf29 Apr 2024: This project will develop and test the safety and effectiveness of new vaccines against EHV induced disease. ... We typically use 7 animals per vaccine group, and we envisage we will test at least 2 candidate vaccines. -
Development of humanised mouse models for study of cancer…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_humanised_mouse_models_for_study_of_cancer_immunotherapy_non-technical_summary_redacted.pdf29 Apr 2024: What's the aim of this project? The aim of this project is to study how the immune system recognises cancer cells, and test the safety and effectiveness of drugs that ... The proposed project will allow a better understanding of how the immune system -
Gut hormone modulation of metabolism (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/gut_hormone_modulation_of_metabolism_non-technical_summary_redacted.pdf30 Apr 2024: Typically such tests will be performed whilst agents that modify gut hormone release or act on gut hormone receptors are also administered, typically directly into the blood stream or into the ... Metabolic fitness test like these will typically involve -
Mechanisms underpinning neuronal excitability in health and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_underpinning_neuronal_excitability_in_health_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: Many of these behavioural tests will monitor the impact of pain on spontaneous behaviours, e.g. ... We also use non-interventional behavioural tests to measure the impact of pain conditions on an animal’s behaviour. -
PPL number: | Granted: 23 Oct 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/evaluation_of_novel_strategies_for_bone_repair_nts_redacted.pdf19 Aug 2021: For the subcutaneous model in rats, small cylinders of the test material will be placed under the skin. ... from one of the test materials, and the bone will be stabilised with a metal orthopaedic plate and screws. -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... body, as well as monitoring how the test agent performs in an intact biological system. -
Epigenetic inheritence and the control of developmental and…
https://www.ubs.admin.cam.ac.uk/system/files/public/epigenetic_inheritance_and_the_control_of_developmental_and_physiological_processes_non-technical_s_redacted.pdf30 Apr 2024: Typically, a mouse will experience each of these above procedures. Some animals will undergo 1, 2 or sometimes 3 behavioural tests typically to test motor skills, anxiety and spatial navigation. ... 3. Methods (test substances, quarantine and monitoring, -
PPL number: | Granted: 18 Feb 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/protection_after_heart_attack_or_stroke_nts_redacted.pdf19 Aug 2021: This project will develop and test novel protective drugs for heart attack and stroke, as well as the resulting organ damage of chronic heart failure or chronic neurological disability, in order ... The main aim of the license is to test protective
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