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28 Feb 2023: By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans, however, we show that the levels of about three-quarters of the nearly 4,000 proteins analyzed in adult animals are

15 Dec 2017: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. ... 3. Jaenisch, R. Transgenic animals. Science 240, 1468–1474 (1988). 4. Jucker, M.

15 Jan 2012: was significantly greater than that in N2 and WT-FUS animals(P , 0.001). ... At 8 days of age,P525L and FUS501 animals are obviously smaller and pale.

15 Jan 2012: model animal systems, such as mice, fish, or primates. In the case of fruit flies, standard assays. ... a Department of Chemistry, University of Cambridge, Cambridge, UK.E-mail: mv245@cam.ac.uk. b Department of Genetics, University of Cambridge, Cambridge

23 Sep 2018: Dobson,†,‡. †Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom‡Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United KingdomDepartment of Experimental

28 Feb 2023: By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans, however, we show that the levels of about three-quarters of the nearly 4,000 proteins analyzed in adult animals are

2 Mar 2023: Xiaoting Yang Centre for Misfolding Diseases, Departmentof Chemistry, University of Cambridge, Cambridge CB21EW, U.K. ... Johnny Habchi Centre for Misfolding Diseases, Departmentof Chemistry, University of Cambridge, Cambridge CB21EW, U.K.

18 Dec 2018: 4Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. ... Data are presented as mean s.e.m. In c, d, f, n = 6 animals, 2 sections per animal; sections with no MC1+ neurons were removed from further analysis,

19 Jan 2017: Dobsona,2. aDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; bUniversity Medical Centre Groningen, European ResearchInstitute for the Biology of Aging, University of Groningen, Groningen 9713 AV, The ... Netherlands;

4 Jun 2020: Salinasb, Tuomas P. J. Knowlesa,Christopher M. Dobsona, and Michele Vendruscoloa,2. aCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom; bResearch Department of Cell& ... Developmental

30 Sep 2009: Immunohistochemical analysis of brain samples from animals that had received Thiamet-G by the oral administration route revealed a similar picture of specific suppres-sion of tau phosphorylation. ... Michele Vendruscolo is in the Department of Chemistry,

25 Feb 2014: Dobson1,. Dale Schenk4, Lisa McConlogue4. 1 Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, 2 SEDIPFAR (Servicio De Descubrimiento, Diseño Y Desarrollo Pre-Clı́nico De Fármacos. ... Information text file S1. Ethics

17 Apr 2019: strategy against AD. https://doi.org/10.1038/s41467-018-07699-5 OPEN. 1 Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. ... 6 Cavendish Laboratory, Department of Physics, University of

4 Oct 2022: Ruggeri,† Michele Perni,†. Tuomas P. J. Knowles,†,‡ Christopher M. Dobson,† and Michele Vendruscolo†,†Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK‡Cavendish Laboratory,

12 Feb 2016: 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. 2Universityof Groningen, University Medical Centre Groningen, European Research Institute for theBiology of Aging, 9700 AD Groningen, Netherlands. ... ampicilin (100 mg/liter) and

22 Jun 2017: 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,Cambridge CB2 1EW, UK.

18 Dec 2018: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,. Cambridge CB2 1EW, UK. ... Prof. Michele Vendruscolo is theco-director of the Centre ofMisfolding Diseases (Universityof Cambridge).

23 Sep 2018: Correspondence to: Christopher M. Dobson, Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB21EW, United Kingdom, E-mail: cmd44@cam.ac.uk; Hilal A. ... Road, University of Cambridge, Cambridge CB2 1EW, United Kingdom, E-mail:

24 Nov 2007: Crowther3,5. 1 Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, 2 Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom,. ... 5 Department of Medicine, University of Cambridge, Cambridge, United Kingdom

31 Mar 2020: Author details1LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.2Centre for Misfolding Diseases, Department of Chemistry, University ofCambridge, Cambridge CB2 1EW, UK. ... ActaNeuropathol 128:755–766.

31 Mar 2020: b Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; c Colorado Division of Parks andWildlife, Wildlife Health Program, Fort Collins, CO 80521-1049; d ... Hamster brains were collected

4 Feb 2020: Dobsona, F. Ulrich Hartlg, and Michele Vendruscoloa,1. aCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom; bGene Function and Evolution,Centre for Genomic Regulation ... By analyzing

30 Sep 2009: Michele Vendruscolo Gian Gaetano Tartaglia. Department of Chemistry, University ofCambridge, Lensfield Road, Cambridge,CB2 1EW, UK. ... Tjian, Transcriptionregulation and animal diversity, Nature,2003, 424, 147–151. 2 E. H.

23 Sep 2018: Chemistry, University of Cambridge, CB2 1EW, UK. To whom correspondence should be addressed. ... MIT Press, Cambridge, MA, USA. He,K. et al. (2015). Deep residual learning for image recognition.

28 Feb 2023: 3Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. ... However, further work in animal models is needed to clarify the effects of clusterin in TSEs.

17 Sep 2017: Furthermore, other. 1Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. ... 2Biopharmaceutical Development, Medimmune Ltd, Granta Park, Cambridge, CB21 6GH, UK. 3Antibody Discovery and Protein Engineering, Medimmune Ltd, Granta Park

5 Dec 2016: 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. ... by Charles River Laboratories(Animal work was approved by the Named Animal Care and Welfare Officer(NACWO) and the Ethics Review Committee of the

13 Jan 2010: Gian Gaetano Tartaglia⁎, Sebastian Pechmann,Christopher M. Dobson and Michele Vendruscolo⁎. Department of Chemistry,University of Cambridge,Lensfield Road, CambridgeCB2 1EW, UK. ... coli. We thus introduce the CamEL(Cambridge Predictor of Expression

15 Mar 2016: J. Knowles, Christopher M. Dobson,and Michele Vendruscolo. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom. ... H. A novelinhibitor of amyloid beta (Abeta) peptide aggregation: From highthroughput screening to efficacy

16 Jan 2011: Dobson,†. Damian C. Crowther, and Leila M. Luheshi††Department of Chemistry and ‡Department of Medicine, Cambridge Institute for Medical Research, and Department of Genetics, University ofCambridge, Cambridge, United Kingdom; and ... only poorly

17 Sep 2017: Per Jemth1. 1Department of Medical Biochemistry and Microbiology, Uppsala University,Uppsala, Sweden; 2Department of Chemistry, University of Cambridge, Cambridge,United Kingdom; 3Department of Chemistry, Technische Universität München,München,

4 Feb 2011: Medical Research Council National Institute for Medical Research, London, UK; and †Departmentof Chemistry, University of Cambridge, Cambridge, UK. ... 2008)SCA3: neurological features, pathogenesis and animal models.Cerebellum 7, 125–137. 18. Saunders

14 Aug 2012: 1Metabolic Research Laboratories, 2National Institute for Health Research Cambridge Biomedical Research Centre, and 3Department of Chemistry, University of Cambridge, Cambridge CB2 0QQ, England, UK. ... IEF of protein extracts from detergent-solubilized

26 May 2018: 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. ... 6Department of Physics, Cavendish Laboratory, Cambridge, UK. 7Present address: German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

1 Mar 2015: Cambridge, Lensfield Road, Cambridge CB2 1EW, UK, 3Department of Neurophysiology, Gunma University Graduate.

16 Jan 2011: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.E-mail: mv245@cam.ac.uk; cmd44@cam.ac.uk.

4 Oct 2013: Montalvao,‡ Lei Shi, Gianluigi Veglia,,. and Michele Vendruscolo,‡. †Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, U.K.‡Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, ... PLN mutations are

28 Nov 2015: 6Institute for Research in Biomedicine, Bellinzona, Switzerland. 7Department of Chemistry, University of Cambridge, Cambridge, UK.

13 Jan 2010: Dobson1. 1Department of ChemistryUniversity of CambridgeLensfield Road, Cambridge CB21EW, UK. 2Dipartimento di ScienzeBiochimiche, Viale Morgagni 50Universitá degli Studi di Firenze50134 Firenze, Italy.

4 Feb 2011: c Dept. of Chemistry, University of Cambridge, Cambridge, UKd Dept. of Physiology and Biochemistry, University of Malta, Maltaw Electronic supplementary information (ESI) available: Text andseven Figures. ... component of bones, skin, ligaments and blood

28 Feb 2023: 2Centre for Misfolding Diseases,Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

28 Sep 2021: In the last 25years, translational studies—including experimental animal andhuman neuropathological, genetic, and in vivo biomarker-basedevidence—support a descriptive hypothetical model of ADpathophysiology characterized by the upstream brain

27 Jun 2009: Pawar1, Silvia Campioni2,Christopher M. Dobson1, Fabrizio Chiti2 and Michele Vendruscolo1⁎. 1Department of Chemistry,University of Cambridge,Lensfield Road, CambridgeCB2 1EW, UK2Dipartimento di ScienzeBiochimiche, Viale Morgagni 50,Universitá

17 Sep 2017: Chemistry, University of Cambridge, Cambridge, United Kingdom;7Structural Genomics Consortium, University of Toronto, Toronto, Canada; 8PrincessMargret Cancer Centre, Toronto, Canada; 9Department of Medical Biophysics,University of Toronto, Toronto,