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Rational design of a conformation-specific antibody for the…
www-vendruscolo.ch.cam.ac.uk/Aprile-2020-PNAS.pdf4 Jun 2020: Salinasb, Tuomas P. J. Knowlesa,Christopher M. Dobsona, and Michele Vendruscoloa,2. aCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom; bResearch Department of Cell& ... Developmental -
pone.0087133 1..11
www-vendruscolo.ch.cam.ac.uk/toth2014po.pdf25 Feb 2014: Dobson1,. Dale Schenk4, Lisa McConlogue4. 1 Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, 2 SEDIPFAR (Servicio De Descubrimiento, Diseño Y Desarrollo Pre-Clı́nico De Fármacos. ... Information text file S1. Ethics -
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity…
www-vendruscolo.ch.cam.ac.uk/limbocker2019nc.pdf17 Apr 2019: strategy against AD. https://doi.org/10.1038/s41467-018-07699-5 OPEN. 1 Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. ... 6 Cavendish Laboratory, Department of Physics, University of -
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers…
www-vendruscolo.ch.cam.ac.uk/mannini2018acscn.pdf4 Oct 2022: Ruggeri,† Michele Perni,†. Tuomas P. J. Knowles,†,‡ Christopher M. Dobson,† and Michele Vendruscolo†,†Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK‡Cavendish Laboratory, -
Science Journals — AAAS
www-vendruscolo.ch.cam.ac.uk/habchi2016sa.pdf12 Feb 2016: 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. 2Universityof Groningen, University Medical Centre Groningen, European Research Institute for theBiology of Aging, 9700 AD Groningen, Netherlands. ... ampicilin (100 mg/liter) and -
Science Journals — AAAS
www-vendruscolo.ch.cam.ac.uk/aprile2017sa.pdf22 Jun 2017: 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,Cambridge CB2 1EW, UK. -
Third generation antibody discovery methods: in silico rational design
www-vendruscolo.ch.cam.ac.uk/sormanni2018csr.pdf18 Dec 2018: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,. Cambridge CB2 1EW, UK. ... Prof. Michele Vendruscolo is theco-director of the Centre ofMisfolding Diseases (Universityof Cambridge). -
Exploring the role of post‐translational modifications in regulating…
www-vendruscolo.ch.cam.ac.uk/elturk2018ps.pdf23 Sep 2018: Correspondence to: Christopher M. Dobson, Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB21EW, United Kingdom, E-mail: cmd44@cam.ac.uk; Hilal A. ... Road, University of Cambridge, Cambridge CB2 1EW, United Kingdom, E-mail: -
A single ultrasensitive assay for detection and discrimination of tau …
www-vendruscolo.ch.cam.ac.uk/Metrick-2020-ANC.pdf31 Mar 2020: Author details1LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.2Centre for Misfolding Diseases, Department of Chemistry, University ofCambridge, Cambridge CB2 1EW, UK. ... ActaNeuropathol 128:755–766. -
plbi-05-11-08 2493..2500
www-vendruscolo.ch.cam.ac.uk/luheshi07pb.pdf24 Nov 2007: Crowther3,5. 1 Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, 2 Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom,. ... 5 Department of Medicine, University of Cambridge, Cambridge, United Kingdom -
SEE COM MEN TARY BIO CHEM ISTR YBI OPH ...
www-vendruscolo.ch.cam.ac.uk/Metrick-2019-PNAS.pdf31 Mar 2020: b Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; c Colorado Division of Parks andWildlife, Wildlife Health Program, Fort Collins, CO 80521-1049; d ... Hamster brains were collected -
Proteome-wide observation of the phenomenon of life on the edge of…
www-vendruscolo.ch.cam.ac.uk/Vecchi-2020-PNAS.pdf4 Feb 2020: Dobsona, F. Ulrich Hartlg, and Michele Vendruscoloa,1. aCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom; bGene Function and Evolution,Centre for Genomic Regulation ... By analyzing -
b805710d 1170..1175
www-vendruscolo.ch.cam.ac.uk/vendruscolo08mb.pdf30 Sep 2009: Michele Vendruscolo Gian Gaetano Tartaglia. Department of Chemistry, University ofCambridge, Lensfield Road, Cambridge,CB2 1EW, UK. ... Tjian, Transcriptionregulation and animal diversity, Nature,2003, 424, 147–151. 2 E. H. -
OP-CBIO180177 2944..2950
www-vendruscolo.ch.cam.ac.uk/liberis2018b.pdf23 Sep 2018: Chemistry, University of Cambridge, CB2 1EW, UK. To whom correspondence should be addressed. ... MIT Press, Cambridge, MA, USA. He,K. et al. (2015). Deep residual learning for image recognition. -
Extracellular protein homeostasis in neurodegenerative diseases
www-vendruscolo.ch.cam.ac.uk/Wilson-2023-NRN.pdf28 Feb 2023: 3Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. ... However, further work in animal models is needed to clarify the effects of clusterin in TSEs. -
Rapid and accurate in silico solubility screening of a monoclonal…
www-vendruscolo.ch.cam.ac.uk/sormanni2017sr.pdf17 Sep 2017: Furthermore, other. 1Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. ... 2Biopharmaceutical Development, Medimmune Ltd, Granta Park, Cambridge, CB21 6GH, UK. 3Antibody Discovery and Protein Engineering, Medimmune Ltd, Granta Park -
Structural basis of synaptic vesicle assembly promoted by…
www-vendruscolo.ch.cam.ac.uk/fusco2016nc.pdf5 Dec 2016: 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. ... by Charles River Laboratories(Animal work was approved by the Named Animal Care and Welfare Officer(NACWO) and the Ethics Review Committee of the -
A Relationship between mRNA Expression Levels and Protein Solubility…
www-vendruscolo.ch.cam.ac.uk/tartaglia09jmb.pdf13 Jan 2010: Gian Gaetano Tartaglia⁎, Sebastian Pechmann,Christopher M. Dobson and Michele Vendruscolo⁎. Department of Chemistry,University of Cambridge,Lensfield Road, CambridgeCB2 1EW, UK. ... coli. We thus introduce the CamEL(Cambridge Predictor of Expression -
co5b00129 1..10
www-vendruscolo.ch.cam.ac.uk/joshi2016acscs.pdf15 Mar 2016: J. Knowles, Christopher M. Dobson,and Michele Vendruscolo. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom. ... H. A novelinhibitor of amyloid beta (Abeta) peptide aggregation: From highthroughput screening to efficacy -
Intrinsic Determinants of Neurotoxic Aggregate Formation by the…
www-vendruscolo.ch.cam.ac.uk/brorsson10bj.pdf16 Jan 2011: Dobson,†. Damian C. Crowther, and Leila M. Luheshi††Department of Chemistry and ‡Department of Medicine, Cambridge Institute for Medical Research, and Department of Genetics, University ofCambridge, Cambridge, United Kingdom; and ... only poorly
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