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The Vendruscolo Laboratory
www-vendruscolo.ch.cam.ac.uk/28 Feb 2023: By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans, however, we show that the levels of about three-quarters of the nearly 4,000 proteins analyzed in adult animals are -
Delivery of Native Proteins into C. elegans Using a Transduction…
www-vendruscolo.ch.cam.ac.uk/perni2017sr.pdf15 Dec 2017: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. ... 3. Jaenisch, R. Transgenic animals. Science 240, 1468–1474 (1988). 4. Jucker, M. -
ALS mutations in FUS cause neuronal dysfunctionand death in ...
www-vendruscolo.ch.cam.ac.uk/murakami12hmg.pdf15 Jan 2012: was significantly greater than that in N2 and WT-FUS animals(P , 0.001). ... At 8 days of age,P525L and FUS501 animals are obviously smaller and pale. -
RSC_IB_C0IB00149J 1..6
www-vendruscolo.ch.cam.ac.uk/kohlhoff11ib.pdf15 Jan 2012: model animal systems, such as mice, fish, or primates. In the case of fruit flies, standard assays. ... a Department of Chemistry, University of Cambridge, Cambridge, UK.E-mail: mv245@cam.ac.uk. b Department of Genetics, University of Cambridge, Cambridge -
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro …
www-vendruscolo.ch.cam.ac.uk/perni2018acb.pdf23 Sep 2018: Dobson,†,‡. †Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom‡Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United KingdomDepartment of Experimental -
The Vendruscolo Laboratory
www-vendruscolo.ch.cam.ac.uk/research.html28 Feb 2023: By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans, however, we show that the levels of about three-quarters of the nearly 4,000 proteins analyzed in adult animals are -
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience …
www-vendruscolo.ch.cam.ac.uk/Joshi-2023-ACSCN.pdf2 Mar 2023: Xiaoting Yang Centre for Misfolding Diseases, Departmentof Chemistry, University of Cambridge, Cambridge CB21EW, U.K. ... Johnny Habchi Centre for Misfolding Diseases, Departmentof Chemistry, University of Cambridge, Cambridge CB21EW, U.K. -
A tau homeostasis signature is linked with the cellular and regional…
www-vendruscolo.ch.cam.ac.uk/fu2019nn.pdf18 Dec 2018: 4Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. ... Data are presented as mean s.e.m. In c, d, f, n = 6 animals, 2 sections per animal; sections with no MC1+ neurons were removed from further analysis, -
A natural product inhibits the initiation of α-synuclein aggregation…
www-vendruscolo.ch.cam.ac.uk/perni2017pnas-ee.pdf19 Jan 2017: Dobsona,2. aDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; bUniversity Medical Centre Groningen, European ResearchInstitute for the Biology of Aging, University of Groningen, Groningen 9713 AV, The ... Netherlands; -
Rational design of a conformation-specific antibody for the…
www-vendruscolo.ch.cam.ac.uk/Aprile-2020-PNAS.pdf4 Jun 2020: Salinasb, Tuomas P. J. Knowlesa,Christopher M. Dobsona, and Michele Vendruscoloa,2. aCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom; bResearch Department of Cell& ... Developmental -
however, excess glucose can lead to an increased flux ...
www-vendruscolo.ch.cam.ac.uk/vendruscolo08ncb.pdf30 Sep 2009: Immunohistochemical analysis of brain samples from animals that had received Thiamet-G by the oral administration route revealed a similar picture of specific suppres-sion of tau phosphorylation. ... Michele Vendruscolo is in the Department of Chemistry, -
pone.0087133 1..11
www-vendruscolo.ch.cam.ac.uk/toth2014po.pdf25 Feb 2014: Dobson1,. Dale Schenk4, Lisa McConlogue4. 1 Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, 2 SEDIPFAR (Servicio De Descubrimiento, Diseño Y Desarrollo Pre-Clı́nico De Fármacos. ... Information text file S1. Ethics -
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity…
www-vendruscolo.ch.cam.ac.uk/limbocker2019nc.pdf17 Apr 2019: strategy against AD. https://doi.org/10.1038/s41467-018-07699-5 OPEN. 1 Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. ... 6 Cavendish Laboratory, Department of Physics, University of -
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers…
www-vendruscolo.ch.cam.ac.uk/mannini2018acscn.pdf4 Oct 2022: Ruggeri,† Michele Perni,†. Tuomas P. J. Knowles,†,‡ Christopher M. Dobson,† and Michele Vendruscolo†,†Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK‡Cavendish Laboratory, -
Science Journals — AAAS
www-vendruscolo.ch.cam.ac.uk/habchi2016sa.pdf12 Feb 2016: 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. 2Universityof Groningen, University Medical Centre Groningen, European Research Institute for theBiology of Aging, 9700 AD Groningen, Netherlands. ... ampicilin (100 mg/liter) and -
Science Journals — AAAS
www-vendruscolo.ch.cam.ac.uk/aprile2017sa.pdf22 Jun 2017: 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,Cambridge CB2 1EW, UK. -
Third generation antibody discovery methods: in silico rational design
www-vendruscolo.ch.cam.ac.uk/sormanni2018csr.pdf18 Dec 2018: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,. Cambridge CB2 1EW, UK. ... Prof. Michele Vendruscolo is theco-director of the Centre ofMisfolding Diseases (Universityof Cambridge). -
Exploring the role of post‐translational modifications in regulating…
www-vendruscolo.ch.cam.ac.uk/elturk2018ps.pdf23 Sep 2018: Correspondence to: Christopher M. Dobson, Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB21EW, United Kingdom, E-mail: cmd44@cam.ac.uk; Hilal A. ... Road, University of Cambridge, Cambridge CB2 1EW, United Kingdom, E-mail: -
plbi-05-11-08 2493..2500
www-vendruscolo.ch.cam.ac.uk/luheshi07pb.pdf24 Nov 2007: Crowther3,5. 1 Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, 2 Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom,. ... 5 Department of Medicine, University of Cambridge, Cambridge, United Kingdom -
A single ultrasensitive assay for detection and discrimination of tau …
www-vendruscolo.ch.cam.ac.uk/Metrick-2020-ANC.pdf31 Mar 2020: Author details1LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.2Centre for Misfolding Diseases, Department of Chemistry, University ofCambridge, Cambridge CB2 1EW, UK. ... ActaNeuropathol 128:755–766.
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