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Enzymatic activity in disordered states of proteins
www-vendruscolo.ch.cam.ac.uk/vendruscolo10cocb.pdf16 Jan 2011: Acc Chem Res 2001,34:938-945. 24. Benkovic SJ, Hammes-Schiffer S: A perspective on enzymecatalysis. -
RESEARCH ARTICLE Translationally optimal codons associate with…
www-vendruscolo.ch.cam.ac.uk/lee10p.pdf16 Jan 2011: Escherichia coli: selection for translational accuracy. Mol. Biol. Evol. 2007, 24, 374–381. ... boundaries in mammals. Mol. Biol. Evol. 2007, 24,. 1600–1603. [31] Warnecke, T., Hurst, L. -
Accurate Determination of Interstrand Distances and Alignment in…
www-vendruscolo.ch.cam.ac.uk/caporini10jpcb.pdf16 Jan 2011: Since a single labeled site in an amyloid fibril monomerforms an extended linear chain of spins when packed into a-sheet fibril, we introduce periodic boundary conditions23,24 intothe simulations to ... chain of infiniteextent and to reduce the -
RSC_mb_C005160H 1..8
www-vendruscolo.ch.cam.ac.uk/pechmann10mbs.pdf16 Jan 2011: Welland andC. M. Dobson, Science, 2009, 326, 1533–1537. 24 A. Wagner, J. ... M. Dobson, Trends Biochem. Sci., 1999, 24, 329–332.70 A. de Marco, E. -
B905825g 277..291
www-vendruscolo.ch.cam.ac.uk/vendruscolo09fd.pdf16 Jan 2011: related phenotypes may be measured allows us to quantify the linksbetween the in vivo toxicity of protein aggregates and the fundamental chemicalproperties of peptides and proteins.24,41,73,74. ... Sci., 1999, 24,329–332. 29 T. R. Jahn and S. E. Radford -
Intrinsic Determinants of Neurotoxic Aggregate Formation by the…
www-vendruscolo.ch.cam.ac.uk/brorsson10bj.pdf16 Jan 2011: in long-term potentiation and synaptic loss (24,25). There-. fore, it appears possible that the I31E mutation can substan-. ... Sci. 24:329–332. 3. Knowles, T. P., A. W. Fitzpatrick,. , M. -
npgrj_nsmb_1562 318..324
www-vendruscolo.ch.cam.ac.uk/friel09nsmb.pdf16 Jan 2011: In(k. ob. s). 0.6. 0.4. 0.2. 0.001 0.01Time (s). 4 6 2 24 46. ... J. Mol. Biol. 366,1001–1015 (2007). 24. Fersht, A.R. Nucleation mechanisms in protein folding. -
Transient Tertiary Structure Formation within the RibosomeExit Port…
www-vendruscolo.ch.cam.ac.uk/obrien10jacs.pdf16 Jan 2011: Sci. 2009, 34, 16–24.(8) Guo, Z. Y.; Thirumalai, D. Biopolymers 1995, 36, 83–102.(9) Dobson, C. ... J. Mol. Biol. 2009, 387, 502–517.(24) Kosolapov, A.; Deutsch, C. Nat. -
Proteome-Level Interplay between Folding and Aggregation Propensities …
www-vendruscolo.ch.cam.ac.uk/tartaglia10jmb2.pdf16 Jan 2011: have suggested that there should be a competitionbetween folding and aggregation,16,19–24 in the sensethat, in order to avoid aggregation, the regions of theamino acid sequence that are highly ... values and have coefficient ofcorrelations of, -
Efficient identification of near-native conformations in ab initio…
www-vendruscolo.ch.cam.ac.uk/wolff10p.pdf16 Jan 2011: RMSD and TM-score (also based on Ca atoms).24 The. root mean square deviation (RMSD) is perhaps the most. ... 7:180. 24. Zhang Y, Skolnick J. Scoring function for automated assessment of.
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