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17 Sep 2017: For correspondence: greta. hultqvist@pubcare.uu.se (GH);. mv245@cam.ac.uk (MV); Per. Jemth@imbim.uu.se (PJ). Competing interests: The. authors declare that no. competing interests exist. Funding: See page 22. Received: 15 March 2016. Accepted: 28

15 Dec 2017: of lipid molecules labeled with aparamagnetic center (PC) were incorporated intothe bilayers (24, 25). ... E. Deas et al., Antioxid. Redox Signal. 24, 376–391 (2016).22. M.

15 Dec 2017: tion exposes new growth competent bril ends through breakage ofrils.12,15,24,25 We model fragmentation by assuming an equal probabilitytation at each monomer in a bril, given by the

17 Sep 2017: For large-mers, the differences in the FRET efficiency histograms are clearly observable, espe-cially at times longer than 24 h. ... b Degradation of the 29 hsamples by the 26S proteasome over 24 h (n = 3, SD, P < 0.05), analyzed by sm-FRET.

17 Sep 2017: 24 C. Woese, S. Winker and R. Gutell, Architecture of ribosomalRNA: constraints on the sequence of ‘‘tetra-loops’’, Proc.Natl.

17 Sep 2017: We determined theapparent dissociation constant of Hsp70 to monomeric αSyn,Kd,M, to be 24 3 μM in the nucleotide-free form and 1.8 0.2μM in the ATP-bound ... 2005) Cell. Mol. Life Sci. 62, 670684.(24) Chen, S. W., Drakulic, S., Deas, E., Ouberai, M.,

17 Sep 2017: I44δ1. 1.0 0.8 0.61H ppm. 26.0. 24.0. 22.0. 15.0. 13.0. 11.0. ... RNF169]/[ub]. RNF169(UDM2). KD=24 7μM. kON. = 2.3 0.7 x 107 M-1 s-1.

17 Sep 2017: VCP (24), sequestosome-1 (25), ubiquilin-2(26), profilin-1 (27), matrin-3 (28), and CCNF (29), as well ashexanucleotide expansions in C9ORF72 (30).At the protein aggregate level, there are

17 Sep 2017: Reduction of disulfide bridges,22 removal ofcofactors,23 truncation of residues at the termini of theprotein,24 or site-directed mutagenesis2527 are some of theapproaches used so far. ... shifts were used for benchmarking (Figure S4; 1.65ppm, 15N; 0.76

15 Dec 2017: Complete conversion was ach-ieved after 24 h at 37 88C, as confirmed by HPLC-MS analysis(Supporting Information, Figures S19 and S20). ... Recently, it hasbeen shown that antibodies against CRM197 neutralizeddiphtheria toxin in HIV infected young