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18 Dec 2018: This journal is The Royal Society of Chemistry 2018 Chem. Soc. Rev., 2018, 47, 9137--9157 | 9137. Cite this: Chem. Soc. Rev., 2018,47, 9137. Third generation antibody discovery methods:in silico rational design. Pietro Sormanni, Francesco A. Aprile

23 Sep 2018: Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitroand in Vivo by TrodusquemineMichele Perni,†,‡, Patrick Flagmeier,†,‡, Ryan Limbocker,†,‡, Roberta Cascella,. Francesco A. Aprile,†,‡ Ceĺine Galvagnion,†,

23 Sep 2018: 0.4. 0.5. 0.6. 0 50 100 150 200. JS d. iver.

23 Sep 2018: cross-validation run on just the 247 structures. We recorded the best class decoy in the top 10 and top 200. ... Binding site Top 10 Top 200 Running time. CDRs 0 2 0 1 14 0 3 h 50 min 19.72 s.

26 May 2018: 0 100 200 300 400. 0.6. 0.8. 1.0. 1.2. 0 10 20 30 40. ... Acce. lerat. ion. Aβ42alone. Aβ42 DMPC:cholesterolvesicles (10% cholesterol). [L]/[P] ratio. 50 200.

23 Sep 2018: phate buffer and pH 5.5, and using a concentration of lysozyme of 200. ... The spectra were measured at 310 K in 50 mM phosphate buffer and pH 5.5, at a concentration oflysozyme of 200 lM using a spectrometer operating at a 1H frequency

18 Dec 2018: umbe. rs). 150250. 200. 150. 100. 50. 0. 200. 150. 100. ... umbe. rs). 800. 700. 600. 500. 400. 300. 200. 100. 0.

23 Sep 2018: The. protein was eluted with a linear gradient of 0–1M. NaCl and subsequently purified on a Superdex 200. ... 12 h at 308C. To insure complete conversion to phos-. phorylated state, 500 lg of 15N a-synuclein wereincubated in 200 lL of reaction volume.

22 Apr 2018: 1. 10. Monomer concentration (μM). Am. plitu. de (. a.u. ). 200. a b c. 150. 100. 50. 00 10 20 30 40. ... in 20 mM sodium phosphate buffer, pH 8, with 200 μ M EDTA and 0.02% NaN3.

23 Sep 2018: 4.9. Transmission Electron Microscopy (TEM). TEM images of hIAPP aggregates obtained in absence or presence of the chaperone variantswere acquired using a Tecnai G2 80–200 kv transmission electron microscope