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Cooperative Assembly of Hsp70 Subdomain Clusters
www-vendruscolo.ch.cam.ac.uk/wright2018b.pdf23 Sep 2018: Chem. 272, 2951129517.(24) Feil, I. K., Malfois, M., Hendle, J., van Der Zandt, H., andSvergun, D. ... M. (2003) Microfluidic devicesfabricated in poly(dimethylsiloxane) for biological studies. Electro-phoresis 24, 35633576.(34) Herling, T. -
Systematic mapping of free energy landscapes of a growing filamin…
www-vendruscolo.ch.cam.ac.uk/waudby2018pnas.pdf27 Sep 2018: Edited by Joseph D. Puglisi, Stanford University School of Medicine, Stanford, CA, and approved July 24, 2018 (received for review September 15, 2017). ... Nat Commun 3:868. 24. Zheng W, Schafer NP, Wolynes PG (2013) Frustration in the energy landscapes -
Reversible inhibition of the ClpP protease via an N-terminal…
www-vendruscolo.ch.cam.ac.uk/vahidi2018pnas.pdf23 Sep 2018: Further, mutations inmitochondrial ClpP are found in patients with Perrault syndrome(23), an autosomal recessive condition associated with hearingloss and ovarian dysgenesis (24). ... B) The cryo-EM density was used torestrain metainference MD -
Third generation antibody discovery methods: in silico rational design
www-vendruscolo.ch.cam.ac.uk/sormanni2018csr.pdf18 Dec 2018: Although the diversity of thehuman antibody repertoire has been estimated to a staggeringB1011 unique sequences,24 it presents certain limitations, suchas biases and redundancy in representing the mutational andconformational space available -
MobiDB 3.0: more annotations for intrinsic disorder, conformational…
www-vendruscolo.ch.cam.ac.uk/piovesan2018nar.pdf22 Apr 2018: as IDEAL (22), DIBS (23) and MFIB (24).IDPs and IDRs can perform key roles in molecular recogni-tion by folding upon binding of short linear motifs (SLiMs)covered in the ... Bioinformatics,doi:10.1093/bioinformatics/btx640. 24. Fichó,E., Reményi,I., -
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro …
www-vendruscolo.ch.cam.ac.uk/perni2018acb.pdf23 Sep 2018: 1, and 0.3 μM) of trodusquemine for 1 h at 37 C under shaking conditions and then addedto the cell culture medium of SH-SY5Y cells for 24 h to ... mortality of the population) of untreated PD worms was about17 1 days, similar to that of control -
Submitted 16 March 2018Accepted 8 June 2018Published 4 July ...
www-vendruscolo.ch.cam.ac.uk/papaleo2018pj.pdf23 Sep 2018: Papaleo et al. (2018), PeerJ, DOI 10.7717/peerj.5125 4/24. Teilum & Poulsen, 2010). ... Papaleo et al. (2018), PeerJ, DOI 10.7717/peerj.5125 8/24. chemical shifts (Fig. -
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic…
www-vendruscolo.ch.cam.ac.uk/michaels2018arpc.pdf22 Apr 2018: There are currently over 50 such conditions that areassociated with the amyloid state (16–19), including Alzheimer’s disease (associated with the ag-gregation of the amyloid-β peptide) (20–24), -
Cholesterol catalyses Aβ42 aggregation through a heterogeneous…
www-vendruscolo.ch.cam.ac.uk/habchi2018nc.pdf26 May 2018: Articleshttps://doi.org/10.1038/s41557-018-0031-x. 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. 1Centre for Misfolding Diseases, -
Molecular determinants of the interaction of EGCG with ordered and…
www-vendruscolo.ch.cam.ac.uk/fusco2018b.pdf23 Sep 2018: 2015, 22, 207. [24] M. Dumoulin, A. M. Last, A. Desmyter, K.
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