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28 Nov 2015: Structure-Free Validation of Residual Dipolar Coupling andParamagnetic Relaxation Enhancement Measurements of DisorderedProteinsFrancisco N. Newby,† Alfonso De Simone,‡ Maho Yagi-Utsumi,†, Xavier Salvatella,. Christopher M. Dobson,† and

1 Mar 2015: Following theprotocol developed using synthetic data for αS,17 24 replicaswere simulated in parallel. ... derived distance restraints were applied to multiple (24)independent replicas simulated in parallel.

28 Nov 2015: While twothermophilic proteins with cyclophilin-like folds have beenpreviously characterized, they are catalytically inactive aspeptidylprolyl isomerases and have likely evolved to fulfillsome other function.24 Therefore, probing the ... dialyzed for 24

28 Nov 2015: By bringing together experiments and computer simulations it has been recently possible to make great progress in characterizing the conformational space of this class of proteins14–24. ... region, (e) 18–24 kJ/mol region and (f) higher region (above

21 Feb 2015: In this type of reaction, the homogeneous primary nucleation21–24 of new oligomers from monomers is inherently a slow process, and it is therefore unlikely to generally represent the major origin ... Nat. Struct. Mol. Biol. 18, 328–336 (2011). 24.

1 Mar 2015: Sci. 24, 329 (1999).5. To access a publicly available protein image database,.

3 Feb 2015: Q Factor for Squalamine RDCs85. NH (AA 170/176) 0.21/0.29 0.14/0.24 0.23/0.40CαHα (AA 170/176) 0.39/0.42 ... Natl. Acad. Sci. U.S.A. 2006, 103, 1090110906.(24) Marsh, J. A.; Forman-Kay, J.

1 Mar 2015: hydrophobic binding pocket adjacent to a-helix 7. (closed inhibitor-bound state).24–27 The interconver-. ... a-helix 7,24–27 in an intermediate state stabilized by. engineered disulfide bonds,22 and in an open active.

28 Nov 2015: The relatively small ΔGDN 2.8 0.1 kcal/molfor the I71V mutant results from a large mutually compensatingenthalpic ΔHDN 24.2 0.1 kcal/mol and an entropic TΔSDN21.4 ... Inparticular, δ2D identified three regions of the D statecorresponding to native

28 Nov 2015: 1D and E).24–34 For example, the extracellular molecularchaperones a2-macroglobulin and clusterin have been shown tointeract with a variety of amyloidogenic proteins to inhibit theformation of fibrils.35–37 ... ref. 24. Feature Article ChemComm. Publ.