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Biophysical approaches for the study of interactions between…
www-vendruscolo.ch.cam.ac.uk/wright2015cc.pdf28 Nov 2015: 1D and E).24–34 For example, the extracellular molecularchaperones a2-macroglobulin and clusterin have been shown tointeract with a variety of amyloidogenic proteins to inhibit theformation of fibrils.35–37 ... ref. 24. Feature Article ChemComm. Publ. -
Identification and characterization of PKCg, a kinaseassociated with…
www-vendruscolo.ch.cam.ac.uk/takahashi2014hmg.pdf1 Mar 2015: 528 Human Molecular Genetics, 2015, Vol. 24, No. 2. at University of C. ... 530 Human Molecular Genetics, 2015, Vol. 24, No. 2. at University of C. -
Rational design of antibodies targeting specificepitopes within…
www-vendruscolo.ch.cam.ac.uk/sormanni2015pnas.pdf10 Aug 2015: In-deed, intrinsic disorder is often observed in peptides and pro-teins implicated in a series of human conditions, including cancer,cardiovascular diseases, and neurodegenerative disorders (22–24). ... Annu Rev Biophys 37:215–246. 24. Knowles TP, -
The s2D Method: Simultaneous Sequence-Based Prediction of the…
www-vendruscolo.ch.cam.ac.uk/sormanni2015jmb-s2d.pdf16 Feb 2015: Article. Pietro Sorman. 0022-2836/ 2014 Elsevi. The s2D Method: Simultaneous Sequence-Based Prediction of the StatisticalPopulations of Ordered and DisorderedRegions in Proteins. ni1, Carlo Camilloni1, Pier. o Fariselli 2 and Michele Vendruscolo1. 1 -
The CamSol Method of Rational Design of Protein Mutants with Enhanced …
www-vendruscolo.ch.cam.ac.uk/sormanni2015jmb-camsol.pdf3 Feb 2015: The otherthree peaks are at 10.7 ml (RH of 24 Å, blue circlelabeled as “3”), also compatible with the RH of themonomeric protein, at 8 ml (RH of 43 Å, -
bi5b00345 1..12
www-vendruscolo.ch.cam.ac.uk/pustovalova2015b.pdf28 Nov 2015: The relatively small ΔGDN 2.8 0.1 kcal/molfor the I71V mutant results from a large mutually compensatingenthalpic ΔHDN 24.2 0.1 kcal/mol and an entropic TΔSDN21.4 ... Inparticular, δ2D identified three regions of the D statecorresponding to native -
The H50Q Mutation Induces a 10-fold Decrease in theSolubility ...
www-vendruscolo.ch.cam.ac.uk/porcari2015jbc.pdf16 Feb 2015: Secondarystructure populations were calculated from chemical shiftsusing the 2D web server (version 1.2) (24). ... J. Mol. Biol. 380, 425– 436. 24. Camilloni, C., De Simone, A., Vranken, W. -
bi5b00670 1..11
www-vendruscolo.ch.cam.ac.uk/newby2015b.pdf28 Nov 2015: Structure-Free Validation of Residual Dipolar Coupling andParamagnetic Relaxation Enhancement Measurements of DisorderedProteinsFrancisco N. Newby,† Alfonso De Simone,‡ Maho Yagi-Utsumi,†, Xavier Salvatella,. Christopher M. Dobson,† and -
NMR characterization of the conformational fluctuations of the human…
www-vendruscolo.ch.cam.ac.uk/leung2014ps.pdf1 Mar 2015: hydrophobic binding pocket adjacent to a-helix 7. (closed inhibitor-bound state).24–27 The interconver-. ... a-helix 7,24–27 in an intermediate state stabilized by. engineered disulfide bonds,22 and in an open active. -
Analysis of the hierarchical structure of the B. subtilis…
www-vendruscolo.ch.cam.ac.uk/kumar2015mbs.pdf1 Mar 2015: coli.24 By analysing a series of recently proposedgraph–theoretic measures25 we quantified the extent of hier-archical organization in the TRNs of the two organisms studiedhere. ... The TRN of E. coliwas extracted from the RegulonDB24 database. After
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