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Biophysical approaches for the study of interactions between…
www-vendruscolo.ch.cam.ac.uk/wright2015cc.pdf28 Nov 2015: 1D and E).24–34 For example, the extracellular molecularchaperones a2-macroglobulin and clusterin have been shown tointeract with a variety of amyloidogenic proteins to inhibit theformation of fibrils.35–37 ... ref. 24. Feature Article ChemComm. Publ. -
ja5b04086 1..11
www-vendruscolo.ch.cam.ac.uk/collepardo2015jacs.pdf28 Nov 2015: molecular dynamics simulationsof dinucleosomes and histone tails with coarse-grained MCsimulations of 24-nucleosome arrays. ... b) Effects of histone tail folding concentration on the compaction of chromatin measured through packing ratiosof -
bi5b00263 1..11
www-vendruscolo.ch.cam.ac.uk/holliday2015b.pdf28 Nov 2015: While twothermophilic proteins with cyclophilin-like folds have beenpreviously characterized, they are catalytically inactive aspeptidylprolyl isomerases and have likely evolved to fulfillsome other function.24 Therefore, probing the ... dialyzed for 24 -
Mapping the Protein Fold Universe Using the CamTube Force Field in…
www-vendruscolo.ch.cam.ac.uk/kukic2015ploscb.pdf28 Nov 2015: We tested the 6–12, 10–12 and 12–24 variants of the n-m potential and found that the 10–12 version provides the best compromise between confinement of the ... PMID: 16624879. 24. Coluzza I (2011) A Coarse-Grained Approach to Protein Design: -
The inverted free energy landscape of an intrinsically disordered…
www-vendruscolo.ch.cam.ac.uk/granata2015sr.pdf28 Nov 2015: By bringing together experiments and computer simulations it has been recently possible to make great progress in characterizing the conformational space of this class of proteins14–24. ... region, (e) 18–24 kJ/mol region and (f) higher region (above -
bi5b00670 1..11
www-vendruscolo.ch.cam.ac.uk/newby2015b.pdf28 Nov 2015: Structure-Free Validation of Residual Dipolar Coupling andParamagnetic Relaxation Enhancement Measurements of DisorderedProteinsFrancisco N. Newby,† Alfonso De Simone,‡ Maho Yagi-Utsumi,†, Xavier Salvatella,. Christopher M. Dobson,† and -
bi5b00345 1..12
www-vendruscolo.ch.cam.ac.uk/pustovalova2015b.pdf28 Nov 2015: The relatively small ΔGDN 2.8 0.1 kcal/molfor the I71V mutant results from a large mutually compensatingenthalpic ΔHDN 24.2 0.1 kcal/mol and an entropic TΔSDN21.4 ... Inparticular, δ2D identified three regions of the D statecorresponding to native -
Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution
www-vendruscolo.ch.cam.ac.uk/brewer2015nsmb.pdf28 Nov 2015: p.m. ). 20.0a. c d. b. e. f. 26.0. 24.0. 22.0. ... 3 nA. 24/4. 24/4. 23/423. /4. 21/4. 23/4. Syt1 KO. Syt1WT. -
bi-2015-00459r 1..10
www-vendruscolo.ch.cam.ac.uk/aprile2015b.pdf10 Aug 2015: U. (2014) Proteostasisimpairment in protein-misfolding and-aggregation diseases. Trends CellBiol. 24, 506514.(8) Hartl, F. ... Rev. Mol. Cell Biol. 8, 101112.(24) Aguzzi, A., and O’Connor, T. -
Rational design of antibodies targeting specificepitopes within…
www-vendruscolo.ch.cam.ac.uk/sormanni2015pnas.pdf10 Aug 2015: In-deed, intrinsic disorder is often observed in peptides and pro-teins implicated in a series of human conditions, including cancer,cardiovascular diseases, and neurodegenerative disorders (22–24). ... Annu Rev Biophys 37:215–246. 24. Knowles TP,
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