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nature14896 493..505
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/95_Brown_A_Nature_2015.pdf19 Aug 2015: with its Watson–Crick edge. ... 4b, c). The main chain of Cys127 from the YxCxxxFmotif can form two hydrogen bonds with the Watson–Crick edge ofA1825 to stabilize its flipped orientation, facilitating stacking of the 12and -
Tyrosine Residues in Phospholipase C�2 Essential for the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11606584.pdf20 Apr 2002: The excitation wavelength was 490 nm, and emission wasmonitored at a wavelength of 535 nm. ... Afterseparation by SDS-PAGE, the gel was subjected to analysis using a PhosphorImager. -
New method to untangle the contribution of signalling pathways…
https://www2.mrc-lmb.cam.ac.uk/new-method-to-untangle-the-contribution-of-signalling-pathways-involved-in-asymmetric-cell-division/28 Sep 2023: In this study, co-led by Joseph Watson and Lara Krüger, the team developed an assay which allows the contribution of each pathway involved in the process to be dissected. ... Watson, JL., Krüger, LK., Ben-Sasson, AJ., Bittleston, A., Shahbazi, M., -
How cellular clocks within heart cells coordinate daily cardiac…
https://www2.mrc-lmb.cam.ac.uk/how-cellular-clocks-within-heart-cells-coordinate-daily-cardiac-rhythms/15 Oct 2021: cells make as great a contribution to daily variation in heart rate as signals from the nervous system. ... Stangherlin, A., Watson, J.L., Wong, D.C.S., Barbiero, S., Zeng, A., Seinkmane, E., Peak Chew, S., Beale, A.D., Hayter, E.A., Guna, A., Inglis, A.J -
PII: S1097-2765(03)00356-3
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/gripdomain.pdf27 Oct 2003: isoleucine makes a shallower contact withof Arf1, corresponding to Tyr 77 in Arl1. ... genes. Proc. Natl. Acad. Sci. USA90, 8952–8956.Analytical UltracentrifugationCollins, B.M., Watson, P.J., and Owen, D.J. -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/download/twinningaandaotherapathologiesa-andreyalebedeva-a/?wpdmdl=18788&refresh=6680101c37a5d171966876411 Jun 2013: 04/06/2013 Crystallography Course LMB 13. a'. a c. c'. Uppenberg et al. ... a. b. Human macrophage receptor CLEC5A for dengue virus Watson, A. -
9780470015902.a0029223
https://www2.mrc-lmb.cam.ac.uk/groups/greger/wp-content/uploads/sites/32/eLS-review_Greger.pdf1 Mar 2022: AMPA ReceptorsAlexandra Pinggera, MRC Laboratory of Molecular Biology, Cambridge, UKJake F Watson, MRC Laboratory of Molecular Biology, Cambridge, UKIngo H Greger, MRC Laboratory of Molecular Biology, Cambridge, UK. ... Science 287 (5461): 2262–2267.DOI -
Supplemental Materials Supp MethodsSupp Fig. 1 Sequence conservation…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004Sup.pdf23 Nov 2004: Q F Q N F L P T V V H P G D L Q T Q L A V Q T K R V A A Q V D ... J Biol Chem278, 46772-46781. Miele, A. E., Watson, P. J., Evans, P. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/28
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/28a/linlia href="#walker"John Walker/a/linlia href="#watson"James Watson/a/lin/uln/div/pnh2 id="arndt"Uli Arndt/h2npimg loading="lazy" decoding="async" width="130" height="200" ... Video Tape: 107 minutes, Wellcome Medical Science Video Archive./linliSee -
Functional Depletion of Mahogunin by Cytosolically Exposed Prion…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/59_Chakrabarti_O_Cell_2009.pdf13 Jun 2009: Some familial PrP mutants generateincreased CtmPrP, a transmembrane isoform associ-ated with disease. ... a direct correlation between the extent of cytosolic PrP exposure. and Mgrn dysfunction. -
Publications
https://www2.mrc-lmb.cam.ac.uk/groups/greger/publications/Commun Biol 4(1): 1056. Watson, J.F., Pinggera, A., Ho, H., Greger, I.H. ... Structure 27(2): 241-252.e3. Buonarati, O.R., Hammes, E.A., Watson, J.F., Greger, I.H., Hell, J.W. -
coot-user-manual.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot-user-manual.pdf28 Sep 2012: 16311.85.2 watson-crick-pair. 16411.85.3 watson-crick-pair-for-residue-range. 164. xix. 11.86 Sequence (Assignment). 16411.86.1 print-sequence-chain. ... Chapter 1: Introduction 2. • a program to do refinement2. • a protein crystallographic suite3. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/9046
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/9046James Watson returned to the LMB to deliver a special talk about Francis Crick, marking the centenary of Francis’ birth.u00a0 Francis and Jim cracked the secret of the DNA structure ... n","protected":false},"excerpt":{"rendered":". James Watson -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_crystallography_course_2013/lectures/pathologies_and_twinning.pdf11 Jun 2013: 04/06/2013 Crystallography Course LMB 13. a'. a c. c'. Uppenberg et al. ... a. b. Human macrophage receptor CLEC5A for dengue virus Watson, A. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/14153
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/14153By simulating the activity of individual synapses on a neuron, seen as deflections in this image for day 100 of #LMB365, Jake Watson in Ingo Gregeru2019s group in Neurobiology can investigate -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/14091
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/14091fluorescent protein which has allowed Jake Watson to visualise them. ... protein which has allowed Jake Watson to visualise them. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/221
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/221factors. n. He then returned to the LMB in 1970 as a staff scientist – a position he held until his retirement in 2008. ... n. The resulting compensating writhe then facilitates the concerted packing of the parallel stacks into a 2-start helical coil. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/19717
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/19717a flat honeycomb structure that can inhibit endocytosis of receptors from the cell surface. ... nnnn. A sheet of proteins (pink and blue) forms a honeycomb-like structure over the surface of a cell. -
https://www2.mrc-lmb.cam.ac.uk/groups/greger/wp-json/wp/v2/pages/15
https://www2.mrc-lmb.cam.ac.uk/groups/greger/wp-json/wp/v2/pages/152003/a/lilia href="#pub2002"2002/a/lilia href="#pub2000"2000/a/lilia href="#pub1998"1998/a/li/ulh3 id="pub2024"2024/h3ul class="lmbpubmedpapers"lispan class="pubAuthors"Stockwell, I., Watson, ... 241-252.e3/span/lilispan class="pubAuthors"Buonarati, O.R., -
Image365 - Page 51 of 61 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-events/image365/page/51/These hold milling cutters concentric to the spindle in a very tight grip. ... protein which has allowed Jake Watson to visualise them. -
Image365 - Page 44 of 61 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-events/image365/page/44/Imagine having a meeting here with this eminent group looking down upon you. ... By simulating the activity of individual synapses on a neuron, seen as deflections in this image for day 100 of #LMB365, Jake Watson in Ingo Greger’s group in Neurobiology -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/14175
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/14175LMB 365 – Day 96"},"content":{"rendered":". Jim Watson was born on this day in 1928. ... n","protected":false},"excerpt":{"rendered":". Jim Watson was born on this day in 1928. He joined the MRC Unit in Cambridge in 1951, where he met and began working -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/8612
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/8612{"id":8612,"date":"2016-03-18T10:46:45","date_gmt":"2016-03-18T10:46:45","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/?p=8612"},"modified":"2024-03-21T17:04:51","modified_gmt":"2024-03-21T17:04:51","slug":"nanostructures-synthetic-genetic-polyme -
LMB In The News - Page 38 of 87 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-events/lmb-in-the-news/page/38/DNA discovery pioneer James Watson pays tribute to colleague Francis Crick. ... Published on. 10 June, 2016. James Watson returned to the LMB to deliver a special talk about Francis Crick, marking the centenary of Francis’ birth. -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/%22https:/www2.mrc-lmb.cam.ac.uk/download/twinningaandaotherapathologiesa-andreyalebedeva-a/?wpdmdl=18788&11 Jun 2013: 04/06/2013 Crystallography Course LMB 13. a'. a c. c'. Uppenberg et al. ... a. b. Human macrophage receptor CLEC5A for dengue virus Watson, A. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/20560
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/20560Cryo-EM structures of a principal AMPA receptor complex in open and closed states provide the first insight into how two major auxiliary subunits modulate receptor function. ... AMPA receptors are a set of membrane proteins that mediate fast signal -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21397
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21397{"id":21397,"date":"2021-10-15T10:14:15","date_gmt":"2021-10-15T09:14:15","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21397"},"modified":"2021-10-28T09:57:04","modified_gmt":"2021-10-28T08:57:04","slug":"how-cellular-clocks-within-heart-cel -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/37738
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/37738It is the hallmark of stem cells, in which one daughter cell specialises to perform a specific function in the organism, while the other becomes another stem cell that keeps the -
Clathrin-mediated endocytosis: Adaptor appendage domains.…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Adaptors/Appendages.html26 Sep 2011: This work is still ongoing. These pages are written to accompany a review by Mills et al 2004. ... Gamma-COP appendage (COPI coat subunit). 1 binding site on the platform subdomain (taken from Hoffman et al 2003 and Watson et al 2004). -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/153768
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/153768{"id":153768,"date":"2023-10-18T16:34:27","date_gmt":"2023-10-18T15:34:27","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=153768"},"modified":"2023-10-18T16:35:03","modified_gmt":"2023-10-18T15:35:03","slug":"new-mechanism-found-that-maintains -
A new 2D protein material for studying receptor endocytosis - MRC…
https://www2.mrc-lmb.cam.ac.uk/a-new-2d-protein-material-for-studying-receptor-endocytosis/6 Jan 2021: Joseph Watson, in Emmanuel’s group, reasoned that such a material could have powerful effects on cells. ... Ben-Sasson, AJ., Watson, JL., Sheffler, W., Johnson, MC., Bittleston, A., Somasundaram, L., Decarreau, J., Jiao, F., Chen, J., Mela, I., Drabek, -
Nanostructures from synthetic genetic polymers - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/nanostructures-synthetic-genetic-polymers/18 Mar 2016: specifically from a series of ‘synthetic genetic polymers’, also known as xeno nucleic acids (XNAs). ... Although distinct from DNA and RNA, the XNAs still carry the bases A, T, C and G, so the standard Watson-Crick base pairing rules still operate -
DNA discovery pioneer James Watson pays tribute to colleague Francis…
https://www2.mrc-lmb.cam.ac.uk/dna-discovery-pioneer-james-watson-pays-tribute-colleague-francis-crick/10 Jun 2016: Search this website. DNA discovery pioneer James Watson pays tribute to colleague Francis Crick. ... Published on. 10 June, 2016. James Watson returned to the LMB to deliver a special talk about Francis Crick, marking the centenary of Francis’ birth. -
https://www2.mrc-lmb.cam.ac.uk/groups/oneill/wp-json/wp/v2/pages/9
https://www2.mrc-lmb.cam.ac.uk/groups/oneill/wp-json/wp/v2/pages/9data-id="https://pubmed.ncbi.nlm.nih.gov/?term=O%27NeillJS&sort=pubdate"here/a. ... For a selection of our most recent, see below:/pnnnnh2 class="wp-block-heading"Most recent articles/h2nnnul class="lmbpubmedpapers"lispan class="pubAuthors"Watson, J.L., -
https://www2.mrc-lmb.cam.ac.uk/groups/shahbazi/wp-json/wp/v2/pages/15
https://www2.mrc-lmb.cam.ac.uk/groups/shahbazi/wp-json/wp/v2/pages/15content":{"rendered":"h3 2024/h3ul class="lmbpubmedpapers"lispan class="pubAuthors"Sato, N., et al./span span class="pubDate"(2024 )/spanbr /a href="http://www.ncbi.nlm.nih.gov/pubmed/38579720" ... ulh3 2023/h3ul class="lmbpubmedpapers"lispan -
https://www2.mrc-lmb.cam.ac.uk/groups/sbullock/wp-json/wp/v2/pages/29
https://www2.mrc-lmb.cam.ac.uk/groups/sbullock/wp-json/wp/v2/pages/29doi: 10.1038/s41594-024-01212-x/span. a href="https://pubmed.ncbi.nlm.nih.gov/38297086/"Pubmed/a/pnpMadan V, Albacete Albacete L, Jin L, Scaturro P, Watson JL, Muschalik ... MAPs, and microtubule ends on directional movement of a localising mRNA./strong -
https://www2.mrc-lmb.cam.ac.uk/groups/sbullock/wp-json/wp/v2/pages/58
https://www2.mrc-lmb.cam.ac.uk/groups/sbullock/wp-json/wp/v2/pages/58doi: 10.1038/s41594-024-01212-x/span. a href="https://pubmed.ncbi.nlm.nih.gov/38297086/"Pubmed/a/pnpMadan V, Albacete Albacete L, Jin L, Scaturro P, Watson JL, Muschalik ... MAPs, and microtubule ends on directional movement of a localising mRNA./strong -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/16108
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/16108Molecular Biology (LMB) and AstraZeneca to support a range of pre-clinical research projects. ... Stangherlin, A., Watson, J.L., Wong, D.C.S., Barbiero, S., Zeng, A., Seinkmane, E., Peak Chew, S., Beale, A.D., Hayter, E.A., Guna, A., Inglis, A.J., Putker, -
All publications
https://www2.mrc-lmb.cam.ac.uk/ccsb/publications/all-publications-2/J. F. Zürcher, A. A. Kleefeldt, L. F. H. Funke, J. ... J. L. Watson, S. Aich, B. Oller-Salvia, A. A. Drakek, S. -
Coot Scripting Interface: c-interface.h File Reference
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface_8h.html24 Aug 2021: if this is not a standard group, then turn the atoms to HETATMs. ... screendump_image (const char filename). dump the current screen image to a file. -
Chin
https://www2.mrc-lmb.cam.ac.uk/ccsb/category/publications/feed/3 Apr 2024: Biol/em/emstrong 2021/strong 220 (2): e202009063./abr / J. L. Watson, S. Aich, B. ... 284-285/a,a href="http://cen.acs.org/magazine/89/8907.html" target="_blank" rel="noopener noreferrer"emChem. -
https://www2.mrc-lmb.cam.ac.uk/groups/greger/wp-json/wp/v2/pages/19
https://www2.mrc-lmb.cam.ac.uk/groups/greger/wp-json/wp/v2/pages/19item fg-type-image fg-idle"figure class="fg-item-inner"a href="https://www2.mrc-lmb.cam.ac.uk/groups/greger/wp-content/uploads/sites/32/398_jake-watson.jpg" ... data-caption-title="Jake Watson" data-attachment-id="102" data-type="image" -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/312
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/312619: 555-562./abr /nJ. F. Zuu0308rcher, A. A. Kleefeldt, L. F. H. ... Biol/em/emstrong 2021/strong 220 (2): e202009063./abr /nJ. L. Watson, S. Aich, B. -
New structures show how auxiliary subunits modulate hippocampal AMPA…
https://www2.mrc-lmb.cam.ac.uk/new-structures-show-how-auxiliary-subunits-modulate-hippocampal-ampa-receptor-neurotransmission/2 Jun 2021: Danyang Zhang, a postdoctoral researcher in Ingo’s group, determined these structures using cryo-EM. ... Zhang, D., Watson, JF., Matthews, PM., Cais, O., Greger, IH. NaturePrevious Insight on Research. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/13500
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/13500Day 362 of #LMB365 shows the LMB Executive Committee after a recent meeting. ... Protein samples frozen on grids in amorphous ice are placed inside a nanocap. -
Jim Watson Outside The Eagle - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fphoto-archive%2Fjim-watson-outside-the-eagle%2F&format=xmlcam.ac.uk/photo-archive/jim-watson-outside-the-eagle/">Jim Watson Outside The Eagle</a></blockquote><iframe sandbox="allow-scripts" security="restricted" ... photo-archive/jim-watson-outside-the-eagle/embed/#?secret=3Rx3odgVgJ" width="600" height="338" -
Reproduction of Watson & Crick DNA Model - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fphoto-archive%2Freproduction-of-watson-crick-dna-model%2F&format=xmlcam.ac.uk/photo-archive/reproduction-of-watson-crick-dna-model/">Reproduction of Watson & Crick DNA Model</a></blockquote><iframe sandbox="allow-scripts" security="restricted" ... ac.uk/photo-archive/reproduction-of-watson-crick-dna-model/embed/#?secret=E -
Pymol guide
https://www2.mrc-lmb.cam.ac.uk/groups/nagai/download/pymolguide.pdf19 Dec 2017: We can see that there are non-Watson-Crick base pairs here, but the cartoon view of the bases doesn’t show the donor and acceptor groups very well. ... To see how the ligand is bound, PyMOL has a really useful tool.
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