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1 - 5 of 5 search results for `Tumour suppressor p53`

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  2. Alan Fersht - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/alan-fersht/
    Thumbnail for Alan Fersht - MRC Laboratory of Molecular Biology 21 Jul 2023: Alan Fersht. Tumour suppressor p53 structure and drug discovery. Alan Fersht was a Natural Sciences undergraduate and Chemistry postgraduate at Gonville and Caius from 1962-68. ... Cancer is a disease of mutation, and the most commonly mutated protein by

  3. Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/merkle
    23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

  4. Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …

    https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/
    23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

  5. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... and Colombo, E.(2011) The lymphoma-associated NPM-ALK oncogene elicits a

  6. Emeritus - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/
    Thumbnail for Emeritus - MRC Laboratory of Molecular Biology 21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.

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