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1 - 10 of 10 search results for `suppressor p53`

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  2. Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK

    https://www.ch.cam.ac.uk/pfei/alan-fersht
    18 Jul 2024: We focus on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53, in order to design novel anti-cancer drugs that function by restoring the activity of ... Cancer is a disease of mutation, and the most commonly mutated

  3. Graduate Poster Display | Pembroke

    https://www.pem.cam.ac.uk/college/news/graduate-poster-display
    19 Jul 2024: Chiba Ene (PhD Medical Sciences) - Histone demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Activity through Lysine Demethylation.

  4. Gerard Evan | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/evan
    23 Jul 2024: a downstream conduit for many (perhaps all) oncogenic growth signals, and a second mouse that models pharmacological restoration of the p53 tumour suppressor, which is functionally inactivated in most human cancers. ... 2011). Validation of MdmX as a

  5. Extra centrosomes and cancer : New light on a century old problem |…

    https://www.gen.cam.ac.uk/news/coelho-extra-centrosomes-and-cancer
    23 Jul 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development.

  6. CDD-MRC Conference on “Genes vs Environment in Cancer” | MRC…

    https://www.mrc-tox.cam.ac.uk/news/cdd-mrc-conference-genes-vs-environment-cancer
    23 Jul 2024: During the conference the Prof. Karen Vousden from The Crick Institute, London, was awarded of the CDD Award 2018 for her pioneering studies on the function of the tumour suppressor protein ... p53 in the response to environmental stressors.

  7. Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/merkle
    23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

  8. Protein engineering pioneer awarded Royal Society Copley Medal |…

    https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal
    18 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel

  9. Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…

    https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/
    Thumbnail for Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular Biology 20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.

  10. Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …

    https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/
    23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

  11. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the

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