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2 Jun 2024: I exploit NMR to study weak multivalent interactions, the role of dynamics in protein function, and to investigate highly plastic systems such as IDPs/IDRs. ... I also study transcription factors that play a key role in cancer such as p53 and MYC.

2 Jun 2024: Projects included an orca sound ocean simulator, numerous artistic projects such as a DNA helix light and programmed light installation displaying the p53 sequence, sensors, drones and more.

2 Jun 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Currently, we have two major projects. "Structural biology of the tumour suppressor p53 and its complexes" in which we are solving the

21 Jul 2023: Currently, we have two major projects. “Structural biology of the tumour suppressor p53 and its complexes” in which we are solving the structure of p53 complexed with its partner proteins, such ... Exploiting Transient Protein States for the Design

n. Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... proteins, such as the Mdm2 and Mdm4, and their complexes.

2 Jul 2021: transcriptional activation of p53-related genes, such as p21 (Brugarolas et al., 1995) and. ... genes may be switched on or off incorrectly, such as the gene coding for the protein p53.

The p53 tumour suppressor is a transcription factor that regulatesthe progression of the cell through its cycle and cell death(apoptosis) in response to environmental stimuli such as DNAdamage and ... Struc-tures dependent upon epidermal mesenchymal

7 Sep 2021: Phase-separated condensates formed by dynamic networks of transactivators, such as OCT4 and GCN4, and coactivators have been shown to enhance gene activation47. ... p62 can drive liquid–liquid phase separation of ubiquitinated proteins, leading to

19 Feb 2016: simultaneously such as the different cyclins, cyclin dependent kinases (CDK), Rb, p53, p21/WAF, and others. • ... Regulators of DNA damage such as p53 and p21/WAF1 can also be included as targets and correlated with the cell cycle phase determined from

6 Jan 2005: ATP binding changes the global properties of theprotein such as a reduction in hydrophobicity15. ... This could facilitate Hsp90’s function asa matchmaker for assembly by binding multipleclient proteins such as p53 and mdm245 or eNOSand PKB/Akt.46 Thus,