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  2. Tyrosine Residues in Phospholipase C�2 Essential for the…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11606584.pdf
    20 Apr 2002: Some of the additional sites couldbe within the 2SA protein (containing 24 tyrosine residues), assuggested in Fig. ... These (Tyr771,Tyr783, and Tyr1254) and some additional sites have been iden-tified after in vitro phosphorylation of purified PLC1 by
  3. pnas201210899 16522..16527

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2012-Aylett-16522-7.pdf
    12 Oct 2012: BmTubR (UniProt Q848W2_BACMQ) lies within an operon con-taining a TubZ homolog in B. ... Proposed ModelBm TubR-DNA. Crystal StructureBt TubR-tubC. Proposedtopological. rearrangement. A B. C D.
  4. The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic …

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Lundmark_McMahon_GRAF2008.pdf
    28 Nov 2008: Although GRAF1 can be found primar-ily on long tubules in some cells, other cells within the samepopulation exhibit a predominantly punctate GRAF1 localiza-tion. ... The depicted images are used to show some of the different morphologies of
  5. Quality and quantity control at the endoplasmic reticulum

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/65_Hegde_RS_COCB_2010.pdf
    7 Jun 2010: B) Lumenal substrates and some membrane proteinsaccess the catalytic site by a translocation-dependent mechanism. ... Indeed, some systems may recruitmachinery that is normally not even used for misfoldedproteins (such as bTrCP).
  6. https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/2034

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/2034
    Nature, 1956, 177, 1124-1125./linliD M Brown, A R Todd & S Varadarajan.br /nThe structures of some acylcytosines. ... Some heterocyclic analogues of stilbenes. J. Chem. Soc., 1948, 2147-2154. D M Brown &B Lythgoe Deoxyribosides and
  7. doi:10.1016/j.cell.2006.03.035

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16647110.pdf
    14 Jun 2006: B) Distribution of IC50 values for selected inhibitors against PI3-K family members. ... Some IC50 values for AMA-37 and TGX-115 have been reported. previously (Knight et al., 2004).
  8. A substrate-specific inhibitor of proteintranslocation into the…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/35_Garrison_JL_Nature_2005.pdf
    15 Jul 2005: 3a, b, and data not shown).Immunoprecipitation studies identified the primary differences(Fig. ... Some of the major depleted proteins are indicated (open arrows). b, As in a, except that samples were analyzed by immunoblotting with PDI , Sec61α , TRAM ,
  9. doi:10.1016/j.jmb.2005.02.053

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/34_Menetret_JF_JMB_2005.pdf
    6 Apr 2005: Separate resolution curves for the ribo-some and the channel were then calculated from theappropriate volumes. ... The resolution of this map is w14.7 Å(FSC0.5, Figure 1(b)) and some surface-exposedrRNA features are lost due to interactions
  10. Evolving nature of the AP2 a-appendage hubduring clathrin-coated…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004.pdf
    23 Nov 2004: B) We found that NECAP does not bind to a-F740Dand thus we probed some mutants around this site along with the top site mutant W840A. ... It is. probable that for steric reasons only some of these motifs can.
  11. Dissertation

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AndyHuang.pdf
    6 Mar 2008: For measuring some features such as body length, body width, velocity and angle. ... during image capture and processing. Some of these features are described in detail:.
  12. SVUS002-16.tex

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/31_Rane_Chapter_2005.pdf
    21 Sep 2006: The second less obvious,but equally plausible possibility (model B) is that neuronal damage re-sults from a derangement in some aspect of normal PrPC metabolism.In this view such altered ... It was therefore logical and simplerto propose that PrPSc
  13. Supplement_Final

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/81_Shao_S_Mol_Cell_2013.pdf
    16 May 2013: poly(A) tail (Figure 2A).Translation of b-VHP-pA produced a heterogeneous set of prod-ucts, some of which contained a tethered tRNA, as evidenced bytheir sensitivity to RNase digestion ... internal polylysine domain (b-VHP-K12) (Figure 2A). As
  14. Protein-driven membrane stresses in fusion and fission

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Kozlov%20Trends%20Biochem%20Sci%202010.pdf
    20 Nov 2010: However, the fusion peptideis clearly more than just a hold on a target membrane,because some amino acid substitutions within the fusionpeptide inhibit fusion without lowering peptide–mem-brane binding. ... 704. membrane stresses, has been confirmed in
  15. 01Eichler(Hedge)

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/33_Hegde_RS_Chapter_2005.pdf
    31 Oct 2005: Indeed, several abundant membrane components havebeen identified associated with the translocon (some with large cytosolic domains such as p180)84. ... 1) provides several. advantages to the cell, some of which are more obvious than others.
  16. Protection from cytosolic prion protein toxicityby modulation of…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/30_Rane_N_EMBO_2004.pdf
    8 Nov 2004: inefficiency in the activity of some signals, we turned our. attention to native PrP. ... some activity. Remarkably, as assessed by either Annexin V. exposure on the extracellular surface (Figure 8A and B) or.
  17. Protein targeting and degradation are coupled for elimination of…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/73_Hessa_T_Nature_2011.pdf
    14 Jul 2011: 3b, c). Thus, the Bag6 complex captures substratesconcomitant with or after the release of nascent chains from the ribo-some; these same hydrophobic domains are bound by the SRP as longas ... After ubiquitination,BAG6 might chaperone its
  18.  The Rockefeller University Press, 0021-9525/97/02/567/15 $2.00The…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/8_Lingappa_JE_JCB_1997.pdf
    3 Feb 1997: SDS-PAGE was per-formed using 15% gels, and some gels were fluorographed using Enhance(Dupont Co., Willmington, DE). ... some of the ma-terial in complexes A, B, and C constitutes intermediatesin the biogenesis of completed 750-S capsids.
  19. doi:10.1016/j.cell.2006.10.032

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/43_Kang_SW_Cell_2006.pdf
    30 Nov 2006: synthesis to degradation) is regulated for at least some. substrates at one time or another. ... observed in some lanes. (B) Analysis of overloaded samples prepared as in (A) reveals increased amounts of BiP in both high-molecular-weight fractions (HMW)
  20. Slide 1

    https://www2.mrc-lmb.cam.ac.uk/download/integration-and-scaling-harry-powell-mrc-lmb-crystallography-course-10th-may-2013/?wpdmdl=18796&refresh=6686ae729870a1720102514
    13 May 2013: the spot intensity.In practice, however, there is always some background, so this needs to be taken into account. ... that spots close to each other on the detector (even on different images) have similar profiles has some validity.
  21. JCB: Article The Rockefeller University Press $30.00J. Cell Biol. ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/J%20Cell%20Biol%202010%20Howes.pdf
    24 Aug 2011: We next sought to verify some key targets as novel cargo for the CLIC pathway. ... In some instances, intriguing tubular networks were seen with labeling for anti–CD44-HRP after 40 min of internal-ization (Fig.

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