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Quality and quantity control at the endoplasmic reticulum
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/65_Hegde_RS_COCB_2010.pdf7 Jun 2010: B) Lumenal substrates and some membrane proteinsaccess the catalytic site by a translocation-dependent mechanism. ... Indeed, some systems may recruitmachinery that is normally not even used for misfoldedproteins (such as bTrCP). -
Features critical for membrane binding revealed by DivIVA crystal…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099a.pdf20 May 2010: Full-length protein is a tetramer, although some non-reversible aggregation also occurred. ... Full assignment is shown. (B) Summary of NMR backbone dynamics showing secondary structure elements and alsothat some residues at the C-terminal end are not -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Kozlov%20Trends%20Biochem%20Sci%202010.pdf20 Nov 2010: However, the fusion peptideis clearly more than just a hold on a target membrane,because some amino acid substitutions within the fusionpeptide inhibit fusion without lowering peptide–mem-brane binding. ... 704. membrane stresses, has been confirmed in -
Crystal Structures of Bacillus subtilis Lon Protease
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/londumanjmb2010.pdf20 Jul 2010: dependent protease FtsH, and thus, Lonproteases of the Lon B type fulfil their roles in theseorganisms.22 Some bacteria, such as Thermotogamaritima, Pseudomonas aeruginosa, and Bacillus sub-tilis, express both Lon ... Some of theseinteractions are of a -
JCB: Article The Rockefeller University Press $30.00J. Cell…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/63_Rane_NS_JCB_2010.pdf16 Feb 2010: This, however, posed some ex-perimental limitations (hence the reason for initially focusing on the more tractable AV3 mutant). ... Some HuPrP(A117V)36 mice also show kyphosis (hunched posture; arrow). (B) The rough hair coat in HuPrP(A117V)36 mice,
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