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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808{"id":21808,"date":"2021-11-24T16:17:22","date_gmt":"2021-11-24T16:17:22","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21808"},"modified":"2024-04-12T12:09:08","modified_gmt":"2024-04-12T11:09:08","slug":"how-dna-damage-induces-appetite-supp -
Publications | Cambridge Infinitus Research Centre
https://circe.ceb.cam.ac.uk/publications1 Jul 2024: Expression-level dependent perturbation of cell proteostasis and nuclear morphology by aggregation-prone polyglutamine proteins, Biotechnol. ... Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric -
Svetlana Khoronenkova | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/khoronenkova1 Jul 2024: Khoronenkova SV, Dianov GL (2013). USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. ... ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. -
Lucia Pinon P Giraldez | MRC Toxicology Unit
https://www.mrc-tox.cam.ac.uk/staff/lucia-pinon-p-giraldez1 Jul 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment. -
Publications | Clarke Group
https://www.ch.cam.ac.uk/group/sclarke/publications?page=230 Jun 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Dr Mattia Frontini | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/mfrontini23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination. -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.pdn.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast1 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast1 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
Therapeutic vulnerabilities in lung tumours with distinct p53…
https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... To identify mutant p53-dependent therapeutic vulnerabilities in lung tumours, Dr Carla Martins and her colleagues at the MRC -
Professor Alan J Warren - Department of Haematology
https://www.haem.cam.ac.uk/staff/senior-staff/professor-alan-j-warren/23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. -
Publications
https://www2.mrc-lmb.cam.ac.uk/groups/jes/publications.html17 Sep 2020: 2020) A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation Stem Cell Reports 32888504. ... and Nakamura, J. (2016). Time- and Dose-Dependent Genotoxicity of Trace Levels of Hexavalent Chromium. -
Search Publications | Publications
https://publications.ch.cam.ac.uk/publications-search?page=16930 Jun 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on -
How DNA damage induces appetite suppression and weight loss - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-dna-damage-induces-appetite-suppression-and-weight-loss/24 Nov 2021: Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation
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Publications | Centre for Atmospheric Science
https://www.ch.cam.ac.uk/group/atm/publications?page=1430 Jun 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Professor Margaret Ashcroft | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/margaretashcroft23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell -
Dr Andrew McKenzie | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/anm%40mrc-lmb.cam.ac.uk23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –. -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast30 Jun 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
BIOINFORMATICS ORIGINAL PAPER Vol. 21 no. 3 2005, pages ...
https://mlg.eng.cam.ac.uk/zoubin/papers/Bioinformatics05beal.pdf27 Jan 2023: An input-dependent SSM can be used to model controlsystems. Another possible way in which the inputs can beutilized is to feedback the outputs (data) from previous timesteps in the sequence ... Weitzman,J. (2000) JunD protects cells from p53-dependent
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