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1 - 9 of 9 search results for `p53 dependent`

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  2. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E

  3. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... To identify mutant p53-dependent therapeutic vulnerabilities in lung tumours, Dr Carla Martins and her colleagues at the MRC

  4. Dr Mattia Frontini | Cambridge Cardiovascular

    https://www.cardiovascular.cam.ac.uk/directory/mfrontini
    23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

  5. Professor Alan J Warren - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/professor-alan-j-warren/
    23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

  6. https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed

    https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed
    23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the

  7. Professor Margaret Ashcroft | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/margaretashcroft
    23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell

  8. Dr Andrew McKenzie | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/anm%40mrc-lmb.cam.ac.uk
    23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –.

  9. https://www.immunology.cam.ac.uk/taxonomy/term/57/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/57/feed
    23 Feb 2024: His recent work is aimed at cell cycle dependent changes inmacrophage biological activity and viral permissivity.

  10. https://www.immunology.cam.ac.uk/taxonomy/term/25/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/25/feed
    23 Feb 2024: PK is a DNA sensor for IRF-3-dependent innate immunity</a></strong></span><br /> <span>BJ Ferguson, DS Mansur, NE Peters, H Ren, GL Smith (2012)</span><span>eLife Sciences ... and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in

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