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1 - 10 of 18 search results for `p53 dependent`

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  2. Publications | Cambridge Infinitus Research Centre

    https://circe.ceb.cam.ac.uk/publications
    3 Jun 2024: Expression-level dependent perturbation of cell proteostasis and nuclear morphology by aggregation-prone polyglutamine proteins, Biotechnol. ... Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric

  3. Svetlana Khoronenkova | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/khoronenkova
    2 Jun 2024: Khoronenkova SV, Dianov GL (2013). USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. ... ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

  4. Lucia Pinon P Giraldez | MRC Toxicology Unit

    https://www.mrc-tox.cam.ac.uk/staff/lucia-pinon-p-giraldez
    2 Jun 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment.

  5. Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…

    https://www.pdn.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast
    2 Jun 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

  6. Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…

    https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast
    2 Jun 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

  7. Publications | Clarke Group

    https://www.ch.cam.ac.uk/group/sclarke/publications?page=2
    2 Jun 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

  8. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E

  9. Dr Mattia Frontini | Cambridge Cardiovascular

    https://www.cardiovascular.cam.ac.uk/directory/mfrontini
    23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

  10. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... To identify mutant p53-dependent therapeutic vulnerabilities in lung tumours, Dr Carla Martins and her colleagues at the MRC

  11. Professor Alan J Warren - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/professor-alan-j-warren/
    23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

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