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Roderik Kortlever, PhD | Bioinformatics Training
https://bioinfotraining.bio.cam.ac.uk/staff/roderik-kortlever-phd23 Jul 2024: René Bernards . Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest. ... Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. -
Svetlana Khoronenkova | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/khoronenkova23 Jul 2024: Khoronenkova SV, Dianov GL (2013). USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. ... ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. -
Lucia Pinon P Giraldez | MRC Toxicology Unit
https://www.mrc-tox.cam.ac.uk/staff/lucia-pinon-p-giraldez23 Jul 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment. -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.pdn.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast23 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast23 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E -
Dr Mattia Frontini | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/mfrontini23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination. -
Publications | Clarke Group
https://www.ch.cam.ac.uk/group/sclarke/publications?page=218 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Therapeutic vulnerabilities in lung tumours with distinct p53…
https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... To identify mutant p53-dependent therapeutic vulnerabilities in lung tumours, Dr Carla Martins and her colleagues at the MRC -
Professor Alan J Warren - Department of Haematology
https://www.haem.cam.ac.uk/staff/senior-staff/professor-alan-j-warren/23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. -
Publications | Centre for Atmospheric Science
https://www.ch.cam.ac.uk/group/atm/publications?page=1418 Jul 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Professor Margaret Ashcroft | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/margaretashcroft23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell -
Dr Andrew McKenzie | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/anm%40mrc-lmb.cam.ac.uk23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –. -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast18 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the -
https://www.immunology.cam.ac.uk/taxonomy/term/57/feed
https://www.immunology.cam.ac.uk/taxonomy/term/57/feed23 Feb 2024: His recent work is aimed at cell cycle dependent changes inmacrophage biological activity and viral permissivity. -
https://www.immunology.cam.ac.uk/taxonomy/term/25/feed
https://www.immunology.cam.ac.uk/taxonomy/term/25/feed23 Feb 2024: PK is a DNA sensor for IRF-3-dependent innate immunity</a></strong></span><br /> <span>BJ Ferguson, DS Mansur, NE Peters, H Ren, GL Smith (2012)</span><span>eLife Sciences ... and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in
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