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{"id":21808,"date":"2021-11-24T16:17:22","date_gmt":"2021-11-24T16:17:22","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21808"},"modified":"2024-04-12T12:09:08","modified_gmt":"2024-04-12T11:09:08","slug":"how-dna-damage-induces-appetite-supp

25 Jul 2024: René Bernards . Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest. ... Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

25 Jul 2024: Khoronenkova SV, Dianov GL (2013). USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. ... ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

25 Jul 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment.

24 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

25 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E

25 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... To identify mutant p53-dependent therapeutic vulnerabilities in lung tumours, Dr Carla Martins and her colleagues at the MRC

23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

17 Sep 2020: 2020) A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation Stem Cell Reports 32888504. ... and Nakamura, J. (2016). Time- and Dose-Dependent Genotoxicity of Trace Levels of Hexavalent Chromium.

24 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

24 Nov 2021: Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation

24 Jul 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell

23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –.

24 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the

27 Jan 2023: An input-dependent SSM can be used to model controlsystems. Another possible way in which the inputs can beutilized is to feedback the outputs (data) from previous timesteps in the sequence ... Weitzman,J. (2000) JunD protects cells from p53-dependent

Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner. ... Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and

11 Nov 1999: 12. Macleod, K. F. et al. p53-dependent and independent expression of p21 during cell growth,. ... et al. Involvement of p85 in p53-dependent apoptotic response to oxidative stress.

23 Feb 2024: His recent work is aimed at cell cycle dependent changes inmacrophage biological activity and viral permissivity.

23 Feb 2024: PK is a DNA sensor for IRF-3-dependent innate immunity</a></strong></span><br /> <span>BJ Ferguson, DS Mansur, NE Peters, H Ren, GL Smith (2012)</span><span>eLife Sciences ... and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in

13 Feb 2023: An input-dependent SSM can be used to model controlsystems. Another possible way in which the inputs can beutilized is to feedback the outputs (data) from previous timesteps in the sequence ... Weitzman,J. (2000) JunD protects cells from p53-dependent

11 Oct 2004: Imaging Biol. 4, 71 (2002). 16. [17] M. Doubrovin et al., Imaging Transcriptional Regulation of p53–Dependent Geneswith Positron Emission Tomography in Vivo, Proc.

2015) Expression-level dependent perturbation of cell proteos-tasis and nuclear morphology by aggregation-prone polyglutamine pro-teins. ... 2015) Long term aggresomeaccumulation leads to DNA damage, p53-dependent cell cycle arrest, andsteric

19 Feb 2016: simultaneously such as the different cyclins, cyclin dependent kinases (CDK), Rb, p53, p21/WAF, and others. • ... Rb is phosphorylated (pRb) in a cell cycle dependent manner (Kaelin, 1999; Mittnacht, 1998).

4 Oct 2021: Legend. Integrated Mitochondrial Protein Index (IMPI) [2021Q4pre-20211001]. Sheets:. 1) Table Legend. 2) IMPI All Human Genes (Ensembl): All human genes with annotation, curation and IMPI localisation score. Ensembl Gene ID: Gene identifier for

12 Apr 2010: activate NOTCH pathways resulting in p53-dependent cell-cycle. arrest (Ban et al., 2008). ... EWS-FLI1 suppresses NOTCH-activated p53 in Ewing’s sarcoma. Cancer. Res. 68, 7100–7109.