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23 Jul 2024: Contributors: Ingrida Olendraite; Katherine Brown; Andrew E. Firth. A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutations. ... Germline and Somatic Genetic Variants in

23 Jul 2024: Inhibition of p53 prevented activation of the DNA damage response during CRISPR/Cas9 treatment and promoted DNA repair via the HDR pathway using the CRISPR repair template as desired. ... A delicate balance is required, however, as p53 inhibition can

23 Jul 2024: Identify novel DNA damage response proteins required for the maintenance of homeostasis in the brain. ... ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

23 Jul 2024: p53 in the response to environmental stressors.

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

23 Jul 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930.

23 Jul 2024: René Bernards . Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest. ... Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression.

12 Jul 2024: Firth</div> </div> </div> <hr /></div> <h4 class="work-title orc-font-body ng-star-inserted" header="">A novel map of human p53 response elements uncovers evidence of selection pressures and ... 084X </a></div> </div> </div> <hr /></div> <h4

12 Jul 2024: TraDIS) to understand the <strong>antimicrobial stress response</strong> in the Enterobacteriaceae species <em>Klebsiella</em>, <em>Salmonella</em> and <em>Enterobacter</em>.</p> </div></div></div><div class="field