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1 - 10 of 13 search results for `p53 response`

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  2. Katy Brown, PhD | Bioinformatics Training

    https://bioinfotraining.bio.cam.ac.uk/staff/katy-brown-phd
    23 Jul 2024: Contributors: Ingrida Olendraite; Katherine Brown; Andrew E. Firth. A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutations. ... Germline and Somatic Genetic Variants in

  3. p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry

    https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells
    23 Jul 2024: Inhibition of p53 prevented activation of the DNA damage response during CRISPR/Cas9 treatment and promoted DNA repair via the HDR pathway using the CRISPR repair template as desired. ... A delicate balance is required, however, as p53 inhibition can

  4. Svetlana Khoronenkova | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/khoronenkova
    23 Jul 2024: Identify novel DNA damage response proteins required for the maintenance of homeostasis in the brain. ... ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

  5. CDD-MRC Conference on “Genes vs Environment in Cancer” | MRC…

    https://www.mrc-tox.cam.ac.uk/news/cdd-mrc-conference-genes-vs-environment-cancer
    23 Jul 2024: p53 in the response to environmental stressors.

  6. Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/pi/huntly
    23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

  7. Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen
    23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

  8. Jussi Taipale | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/taipale
    23 Jul 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930.

  9. Roderik Kortlever, PhD | Bioinformatics Training

    https://bioinfotraining.bio.cam.ac.uk/staff/roderik-kortlever-phd
    23 Jul 2024: René Bernards . Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest. ... Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

  10. Professor Alan Warren | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/warren
    23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.

  11. Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/brian-huntly
    23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

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