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Therapeutic vulnerabilities in lung tumours with distinct p53…
https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/23 Feb 2024: models harboring distinct p53 deficiencies, namely complete loss of p53 (Null); mutations that cause loss of p53 contact with DNA and mutations that alter the correct conformation of the protein. ... of this therapeutic approach even when p53 mutations -
Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/arf251 Jun 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. -
Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Featured Articles Archives - Page 14 of 32 - School of Clinical…
https://www.medschl.cam.ac.uk/category/feature/page/14/23 Feb 2024: September 5, 2017. The KRAS oncogene is frequently activated by mutations in cancers (including 90% of pancreatic cancers and 30-40% of colorectal or lung cancers). ... Approximately half of lung adenocarcinomas, the most common type of lung cancer, -
Greta Skrupskelyte | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/directory/great-skrupskelyte23 Feb 2024: 2018) Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations. -
Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/merkle23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation ... novel methods to identify culture conditions -
Publications
https://www-neurosciences.medschl.cam.ac.uk/horvathlab/publications/23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. ... EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. -
p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry
https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells2 Jun 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations. -
Search Publications | Publications
https://publications.ch.cam.ac.uk/publications-search?page=5862 Jun 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on -
School News Archives - Page 12 of 29 - School of Clinical Medicine
https://www.medschl.cam.ac.uk/category/schoolnews/page/12/23 Feb 2024: by mutations in cancers (including 90% of pancreatic cancers and 30-40% of colorectal or lung cancers). ... Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the
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