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1 Jul 2024: Search site. Department of Biochemistry. Vehicle Pool. The University of Cambridge is an institution located over several sites spread throughout the city of Cambridge, which can frequently cause logistical difficulties for members of staff. The

1 Jul 2024: Search site. Department of Biochemistry. Darerca Owen. Darerca Owen. Small G protein-regulated signalling networks. Small G proteins of the Ras superfamily are essential components to almost all processes of cell biology and since they were

1 Jul 2024: Search site. Department of Biochemistry. PhD Symposium 2019. The Department recently held its first PhD Symposium, serving as the new centrepiece of our annual celebration of our research strengths and activities. The Symposium brought together our

1 Jul 2024: Search site. Department of Biochemistry. About the Department. Department of Biochemistry. About us. The Department of Biochemistry at the University of Cambridge is a world-leading biochemical research and education facility, building on the

1 Jul 2024: Search site. Department of Biochemistry. Eyal Maori. RNA transmission between organisms. The Maori Group is broadly interested in the RNA interconnections of infection, immunity and genome dynamics. We are studying how RNA flows between individuals,

1 Jul 2024: Author. Adapted from University of Cambridge: Environment and Energy news article.

1 Jul 2024: We want to create a community where alumni can find old friends and we can reconnect to share news, advice, and expertise.

1 Jul 2024: Search site. Department of Biochemistry. Nianshu Zhang. Stress response and ageing in yeast. Caloric restriction (CR) without malnutrition extends lifespan in most model organisms tested, including rhesus monkeys. Their lifespan extension by CR is

1 Jul 2024: Search site. Department of Biochemistry. Pellegrini Group. Pellegrini Group website. Macromolecular mechanisms of genome duplication and stability. The faithful inheritance of genetic information is essential to cellular life. Successful

1 Jul 2024: Search site. Department of Biochemistry. Daniel Nietlispach. Integral membrane protein biology: structure, dynamics and function. Lipid-embedded integral membrane proteins are highly abundant due to their relevance for cellular function. The

1 Jul 2024: Search site. Department of Biochemistry. Mott and Owen Group. Mott and Owen Group website. Welcome to the website of the lab of Darerca Owen and Helen Mott. We co-run a research team who are interested in the structures and functions of small G

1 Jul 2024: Search site. Department of Biochemistry. Luca Pellegrini. Luca Pellegrini. Molecular mechanisms of genomic stability. Every time a cell divides it must duplicate its genome accurately and completely. Genetic inheritance relies on DNA replication,

1 Jul 2024: Search site. Department of Biochemistry. Introduction. Department of Biochemistry. Intranet. Welcome to the Department Intranet site for all members of the Department. Access to Intranet pages (using your Raven password) is available for those who

1 Jul 2024: Search site. Department of Biochemistry. Current Faculty. Current Faculty. Bill Broadhurst. Structural dynamics of modular polyketide synthases. . Read more at: Guy Brown.. Guy Brown. Microglia in neuroinflammation and neurodegeneration. . Read more

1 Jul 2024: Search site. Department of Biochemistry. Peter Leadlay. Molecular assembly lines and combinatorial biosynthesis. Key publications. Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF, Leadlay PF (2007). Complete genome

1 Jul 2024: Search site. Department of Biochemistry. Fund for the future. Support us. Would you like to have a real impact on future discoveries with potential to benefit all? At the Department of Biochemistry we do, and we want you to be part of this. The

1 Jul 2024: Search site. Department of Biochemistry. Ross Waller. Investigating molecular function, diversity and evolution in cells. It was amongst unicellular eukaryotes (protists) that complex cell architectures and compartmentalisation were developed that

1 Jul 2024: Search site. Department of Biochemistry. Teaching in Biochemistry. Department of Biochemistry. Undergraduate Teaching. Teaching in Biochemistry. The Department of Biochemistry contributes to teaching a number of courses in the Natural Sciences

1 Jul 2024: Search site. Department of Biochemistry. Guy Brown. Microglia in neuroinflammation and neurodegeneration. We are interested in the mechanisms of neuroinflammation and neurodegeneration in the brain. We use mouse models of disease and cultured brain

1 Jul 2024: The BioPath Stores Facility offers direct access and competitive pricing for an extensive inventory of over 3,500 products, including both tried-and-tested core stock items and the latest in

1 Jul 2024: Search site. Department of Biochemistry. Jean Thomas. Chromatin and gene regulatory proteins. Key publications. Thomas JO, Travers AA (2001). HMG1 and 2, and related 'architectural' DNA-binding proteins. Trends Biochem. Sci., 26(3):167-174. doi:

1 Jul 2024: The Team are vastly experienced in printing posters on paper and foldable canvas material, with an express poster printing service available to allow you to present your very latest data at

1 Jul 2024: Search site. Department of Biochemistry. Steve Oliver. Functional genomics and systems biology. Key publications. Oliver SG (2022). From Petri plates to Petri nets, a revolution in yeast biology. FEMS Yeast Res., 22(1):foac008. doi:

1 Jul 2024: Search site. Department of Biochemistry. COVID-19 projects. COVID-19 projects. Modulation of host cell RNA-binding proteins through the infectious cycle of SARS-CoV-2. Kathryn Lilley and her long-term collaborator, Anne Willis (MRC Toxicology Unit),

1 Jul 2024: Search site. Department of Biochemistry. Tom Blundell. Understanding in space and time multicomponent systems involved in cell regulation and targeting them in cancer and mycobacterial infections. The Blundell Group focuses on structural and

1 Jul 2024: Search site. Department of Biochemistry. Mark Carrington. Molecular cell biology of trypanosomes. The current diversity in eukaryotic life has evolved from the last common eukaryotic ancestor over more than one billion years. Early in this series of

1 Jul 2024: Search site. Department of Biochemistry. Sarah Lummis. Characterisation of Cys-loop receptors. The Cys-loop or pentameric ligand-gated ion channel (pLGIC) family of neurotransmitter-gated channels provide rapid signal transmission at neuronal

1 Jul 2024: Search site. Department of Biochemistry. Ernest Laue. Ernest Laue. Chromatin remodelling and genome structure. The Laue Group is interested in the way chromatin structure controls gene expression, and studies the structure and function of protein

1 Jul 2024: Search site. Department of Biochemistry. Chris Howe. Chris Howe. Biochemistry of photosynthetic organisms and their non-photosynthetic relatives. The Howe Group works on several topics to do with photosynthetic organisms and their relatives.

1 Jul 2024: Search site. Department of Biochemistry. Trevor Littlewood. Oncogenic signalling in cancer. Understanding the molecular activities of oncogenes and how they interact functionally to drive and maintain tumours is central to the identification of

1 Jul 2024: Search site. Department of Biochemistry. Chris Smith. Regulation of alternative pre-mRNA splicing. Alternative pre-mRNA splicing (AS) allows individual genes to encode large numbers of functionally distinct proteins, and is a key mechanism that

1 Jul 2024: Search site. Department of Biochemistry. Marc de la Roche. Marc de la Roche. The Wnt pathway in normal homeostasis and disease. The Wnt pathway is an intracellular series of events culminating on a gene expression program that regulates various

1 Jul 2024: Search site. Department of Biochemistry. Richard Farndale. Collagen receptors and collagen-binding proteins. Key publications. Farndale RW, Lisman T, Bihan D, Hamaia S, Smerling CS, Pugh N, Konitsiotis A, Leitinger B, de Groot PG, Jarvis GE, Raynal

1 Jul 2024: Search site. Department of Biochemistry. Robin Hesketh. Growth of solid tumours. Key publications. Kirschenlohr H, Ellis P, Hesketh R, Metcalfe J (2012). Gene expression profiles in white blood cells of volunteers exposed to a 50 Hz electromagnetic

1 Jul 2024: Search site. Department of Biochemistry. Jim Metcalfe. Transforming growth factor-beta signalling pathways. Key publications. Kirschenlohr H, Ellis P, Hesketh R, Metcalfe J (2012). Gene expression profiles in white blood cells of volunteers exposed

1 Jul 2024: Search site. Department of Biochemistry. Affiliate and Associate faculty. Affiliated and Associate faculty. John McCafferty. Cell-cell interactions. . Read more at: Andrew Grace.. Andrew Grace. Cellular genetics of cardiac excitability. . Read more

1 Jul 2024: Search site. Department of Biochemistry. Kevin Brindle. Molecular imaging of cancer. The inter- and intra-patient genetic heterogeneity of tumours means that different patients, with ostensibly the same tumour type, may respond differently to the

1 Jul 2024: Search site. Department of Biochemistry. Former faculty. Former faculty. Philip Zegerman. Regulation of DNA replication initiation in eukaryotes. . Read more at: Svetlana Khoronenkova.. Svetlana Khoronenkova. DNA repair and neurodegenerative diseases

1 Jul 2024: Search site. Department of Biochemistry. Bill Broadhurst. Structural dynamics of modular polyketide synthases. Modular polyketide synthases (PKSs) are among the largest integrated enzyme complexes known, organizing clusters of catalytic domains

1 Jul 2024: Search site. Department of Biochemistry. Marko Hyvönen. Specificity, regulation and inhibition of protein-protein interactions in cellular signalling. Summary:. Our research is aiming to understand how cells in humans communicate with each other,

1 Jul 2024: Search site. Department of Biochemistry. Nick Gay. Molecular and cellular mechanisms of innate immunity. Chronic inflammation plays a central role in many debilitating diseases such as arthritis, sepsis, cancer and Parkinson's disease (PD). The

1 Jul 2024: Search site. Department of Biochemistry. Shilo Titus. DNA sequencing. The Department's DNA Sequencing Facility was established in the 1990s by Professor Peter Leadlay, and his Laboratory Manager, John Lester, was seconded to manage it day to day.

1 Jul 2024: Search site. Department of Biochemistry. Svetlana Khoronenkova. DNA repair and neurodegenerative diseases. Human cells repair thousands of DNA lesions daily. The majority of lesions arise from the intrinsic chemical instability of DNA and include

1 Jul 2024: Search site. Department of Biochemistry. Tony Jackson. Sodium channels and other plasma membrane proteins. In electrically-excitable cells, the voltage-gated sodium (Nav) channel initiates the action potential. Sodium channels are major

1 Jul 2024: Search site. Department of Biochemistry. Philip Zegerman. Regulation of DNA replication initiation in eukaryotes. A fundamental requirement for all life on Earth is that an exact copy of the entire genome must be made before cell division. Failures

1 Jul 2024: Search site. Department of Biochemistry. Jussi Taipale. Transcriptional control of growth. Decades of work by biological scientists have revealed many fundamental mechanisms of life, yet several questions remain unanswered. This is in part because

1 Jul 2024: Search site. Department of Biochemistry. Facility Managers. Facility Managers. Dima Chirgadze. Cryo-Electron Microscopy Facility. . Read more at: Shilo Titus.. Shilo Titus. DNA Sequencing Facility. . Read more at: Katherine Stott.. Katherine Stott.

1 Jul 2024: Search site. Department of Biochemistry. Gerard Evan. Determining the molecular basis of cancer. Cancers are lethal diseases in desperate need of new therapeutic approaches: despite dramatic advances in the use of conventional chemo and radiotherapy

1 Jul 2024: Search site. Department of Biochemistry. Jenny Gallop. Signalling to the actin cytoskeleton. Cells move during embryonic development and throughout the life of an organism. When they move, cells reorganise a system of filaments (the actin

1 Jul 2024: Search site. Department of Biochemistry. Camilla Godlee. Investigating the interactions of pathogenic bacteria with eukaryotic membranes. In the Godlee group we are studying how bacterial virulence proteins interact with eukaryotic membranes during