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FRET Imaging of Hemoglobin Concentration in Plasmodium…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/fret-imaging-of-hemoglobin-concentration-in-plasmodium-falciparum-infected-red-cells22 Jul 2024: Search site. Laser Analytics Group. FRET Imaging of Hemoglobin Concentration in Plasmodium falciparum-Infected Red Cells. Esposito A, Tiffert T, Mauritz J, Schlachter S, Bannister LH, Kaminski CF, Lew VL, "FRET Imaging of Haemoglobin Concentration -
Ellipsoid localisation microscopy infers the size and order of…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/ellipsoid-localisation-microscopy-infers-the-size-and-order-of-protein-layers-in-bacillus-spore-coats22 Jul 2024: Software for download. -
Probing Amyloid Aggregation and Morphology In Situ by Multiparameter…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/probing-amyloid-aggregation-and-morphology-in-situ-by-multiparameter-imaging-and-super-resolution-fluorescence-microscopy22 Jul 2024: Search site. Laser Analytics Group. Probing Amyloid Aggregation and Morphology In Situ by Multiparameter Imaging and Super-Resolution Fluorescence Microscopy. Probing Amyloid Aggregation and Morphology In Situ by Multiparameter Imaging and -
In Situ Measurements of the Formation and Morphology of Intracellular …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/in-situ-measurements-of-the-formation-and-morphology-of-intracellular-ss-amyloid-fibrils-by-super-resolution-fluorescence-imaging22 Jul 2024: Our data support the recent view that intracellular Aβ could be associated with Aβ pathogenicity in AD, although the major deposits are extracellular, and suggest that this approach will be widely -
Quasi Instantaneous 2-Dimensional Temperature Measurements in…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/quasi-instantaneous-2-dimensional-temperature-measurements-in-combustion-by-atomic-laser-induced-fluorescence22 Jul 2024: Search site. Laser Analytics Group. Quasi Instantaneous 2-Dimensional Temperature Measurements in Combustion by Atomic Laser Induced Fluorescence. Kaminski, CF, Engström, J, Aldén, M, "Quasi Instantaneous 2-Dimensional Temperature Measurements in -
Correlative AFM-FLIM Measurements in Living Cells, Tissues and in…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/correlative-afm-flim-measurements-in-living-cells-tissues-and-in-solar-cell-materials22 Jul 2024: Search site. Laser Analytics Group. Correlative AFM-FLIM Measurements in Living Cells, Tissues and in Solar Cell Materials. Poudel C, Mela I, Ananya M, Delport G, Stranks SD, Kaminski CF. "Correlative AFM-FLIM Measurements in Living Cells, Tissues -
Applications and evaluation of two-line atomic LIF thermometry in…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/applications-and-evaluation-of-two-line-atomic-lif-thermometry-in-sooting-combustion-environments22 Jul 2024: Search site. Laser Analytics Group. Applications and evaluation of two-line atomic LIF thermometry in sooting combustion environments. Nygren, J; Engstrom, J; Walewski, J; Kaminski, CF; Alden, M, "Applications and evaluation of two-line atomic LIF -
Structural progression of amyloid- Arctic mutant aggregation in cells …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/structural-progression-of-amyloid-arctic-mutant-aggregation-in-cells-revealed-by-multiparametric-imaging22 Jul 2024: Our findings uncover the structural basis of the progression of Arctic mutant A42 aggregation in the cell. -
Periodic interactions between solitons and dispersive waves during…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/periodic-interactions-between-solitons-and-dispersive-waves-during-the-generation-of-noncoherent-supercontinuum-radiation22 Jul 2024: Search site. Laser Analytics Group. Periodic interactions between solitons and dispersive waves during the generation of noncoherent supercontinuum radiation. Liu C, Rees EJ, Laurila T, Jian S, Kaminski CF, "Periodic interactions between solitons -
Establishment of the ac electrokinetic elongation mechanism of DNA by …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/establishment-of-the-ac-electrokinetic-elongation-mechanism-of-dna-by-three-dimensional-fluorescent-imaging22 Jul 2024: Search site. Laser Analytics Group. Establishment of the ac electrokinetic elongation mechanism of DNA by three-dimensional fluorescent imaging. Walti, C; Tosch, P; Davies, AG; Germishuizen, WA; Kaminski, CF, "Establishment of the ac electrokinetic -
Two-photon polarization spectroscopy and (2+3)-photon laser induced…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/two-photon-polarization-spectroscopy-and-2-3-photon-laser-induced-fluorescence-of-n-222 Jul 2024: Search site. Laser Analytics Group. Two-photon polarization spectroscopy and (23)-photon laser induced fluorescence of N-2. Kaminski, CF; Löfstedt, B; Fritzon, R; Alden, M, "Two-photon polarization spectroscopy and (23)-photon laser induced -
A guide to structured illumination TIRF microscopy at high speed with …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/a-guide-to-structured-illumination-tirf-microscopy-at-high-speed-with-multiple-colors22 Jul 2024: Search site. Laser Analytics Group. A guide to structured illumination TIRF microscopy at high speed with multiple colors. Young LJ, Ströhl F, Kaminski CF "A guide to structured illumination TIRF microscopy at high speed with multiple colors", JOVE -
From single-molecule spectroscopy to super-resolution imaging of the…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/from-single-molecule-spectroscopy-to-super-resolution-imaging-of-the-neuron-a-review-122 Jul 2024: Search site. Laser Analytics Group. From single-molecule spectroscopy to super-resolution imaging of the neuron: a review. Laine RF, Kaminski Schierle GS, van de Linde S, Kaminski CF, "From single-molecule spectroscopy to super-resolution imaging of -
A calibration method for broad-bandwidth cavity enhanced absorption…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/a-calibration-method-for-broad-bandwidth-cavity-enhanced-absorption-spectroscopy-performed-with-supercontinuum-radiation22 Jul 2024: Search site. Laser Analytics Group. A calibration method for broad-bandwidth cavity enhanced absorption spectroscopy performed with supercontinuum radiation. T. Laurila, I.S. Burns, J. Hult, J.H. Miller and C.F. Kaminski, "A calibration method for -
Dependence of partially saturated polarization spectroscopy signals…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/dependence-of-partially-saturated-polarization-spectroscopy-signals-on-pump-intensity-and-collision-rate22 Jul 2024: compared to both results from the DNI calculations and to our proposed analytical equation. ... Our simple model provides excellent fits to polarizationspectroscopy-saturation curves for absorption lines dominated by homogeneous broadening and for -
TestSTORM: Simulator for optimizing sample labeling and image…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/teststorm-simulator-for-optimizing-sample-labeling-and-image-acquisition-in-localization-based-super-resolution-microscopy22 Jul 2024: Search site. Laser Analytics Group. TestSTORM: Simulator for optimizing sample labeling and image acquisition in localization based super-resolution microscopy. TestSTORM: Simulator for optimizing sample and image acquisition in localization based -
High-repetition-rate combustion thermometry with two-line atomic…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/high-repetition-rate-combustion-thermometry-with-two-line-atomic-fluorescence-excited-by-diode-lasers22 Jul 2024: At a repetition rate of 3.5 kHz our technique offers a precision of 1.5% at 2000 K in laminar methane/air flames. -
Investigating state restriction in fluorescent protein FRET using…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/investigating-state-restriction-in-fluorescent-protein-fret-using-time-resolved-fluorescence-and-anisotropy22 Jul 2024: Search site. Laser Analytics Group. Investigating state restriction in fluorescent protein FRET using time-resolved fluorescence and anisotropy. Blacker TS, Chen WY, Avezov E, Marsh RJ, Duchen MR, Kaminski CF, Bain AJ, "Investigating state -
Tomographic absorption spectroscopy for the study of gas dynamics and …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/tomographic-absorption-spectroscopy-for-the-study-of-gas-dynamics-and-reactive-flows22 Jul 2024: Search site. Laser Analytics Group. Tomographic absorption spectroscopy for the study of gas dynamics and reactive flows. Cai W, Kaminski CF, "Tomographic absorption spectroscopy for the study of gas dynamics and reactive flows", PECS. (2017), 59, -
Temperature treatment of highly porous zirconium-containing…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/temperature-treatment-of-highly-porous-zirconium-containing-metal2013organic-frameworks-extends-drug-delivery-release22 Jul 2024: Search site. Laser Analytics Group. Temperature treatment of highly porous zirconium-containing metal–organic frameworks extends drug delivery release. Teplensky MH, Fantham M, Li P, Wang TC, Mehta JP, Young LJ, Moghadam PZ, Hupp JT, Farha OK, -
HomoFRET fluorescence anisotropy imaging as a tool to study molecular …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/homofret-fluorescence-anisotropy-imaging-as-a-tool-to-study-molecular-self-assembly-in-live-cells22 Jul 2024: Search site. Laser Analytics Group. HomoFRET fluorescence anisotropy imaging as a tool to study molecular self-assembly in live cells. Chan FTS, Kaminski CF, and Kaminski Schierle, "HomoFRET fluorescence anisotropy imaging as a tool to study -
Chemiluminescence sensor for local equivalence ratio of reacting…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/chemiluminescence-sensor-for-local-equivalence-ratio-of-reacting-mixtures-of-fuel-and-air-flameseek22 Jul 2024: Search site. Laser Analytics Group. Chemiluminescence sensor for local equivalence ratio of reacting mixtures of fuel and air (FLAMESEEK). Hardalupas, Y; Orain, M; Panoutsos, CS; Taylor, AMKP; Olofsson, J; Seyfried, H; Richter, M; Hult, J; Alden, M; -
From single-molecule spectroscopy to super-resolution imaging of the…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/from-single-molecule-spectroscopy-to-super-resolution-imaging-of-the-neuron-a-review22 Jul 2024: Search site. Laser Analytics Group. From single-molecule spectroscopy to super-resolution imaging of the neuron: a review. From single-molecule spectroscopy to super-resolution imaging of the neuron: a review" Laine RF, Kaminski Schierle GS, van de -
Fluorescence intensity and lifetime imaging of free and…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/fluorescence-intensity-and-lifetime-imaging-of-free-and-micellar-encapsulated-doxorubicin-in-living-cells22 Jul 2024: Search site. Laser Analytics Group. Fluorescence intensity and lifetime imaging of free and micellar-encapsulated doxorubicin in living cells. Dai X, Yue Z, Eccleston M, Swartling J, Slater N, Kaminski CF, "Fluorescence intensity and lifetime -
Optical superresolution techniques for the study of β-amyloid…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/optical-superresolution-techniques-for-the-study-of-b-amyloid-aggregation-in-vitro-and-in-vivo-novel-methods-and-strategies22 Jul 2024: Search site. Laser Analytics Group. Optical superresolution techniques for the study of β-amyloid aggregation in vitro and in vivo: Novel methods and strategies. Pinotsi D, Kaminski-Schierle G S, Kaminski C F, "Optical superresolution techniques -
A concept for single-shot volumetric fluorescence imaging via…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/a-concept-for-single-shot-volumetric-fluorescence-imaging-via-orthogonally-polarized-excitation-lattices22 Jul 2024: Search site. Laser Analytics Group. A concept for single-shot volumetric fluorescence imaging via orthogonally polarized excitation lattices. Ströhl F, Kaminski CF. "A concept for single-shot volumetric fluorescence imaging via orthogonally -
High repetition rate planar laser induced fluorescence of OH in a…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/high-repetition-rate-planar-laser-induced-fluorescence-of-oh-in-a-turbulent-non-premixed-flame22 Jul 2024: Search site. Laser Analytics Group. High repetition rate planar laser induced fluorescence of OH in a turbulent non-premixed flame. Kaminski, CF; Hult, J; Alden, M, "High repetition rate planar laser induced fluorescence of OH in a turbulent -
MiLeSIM: combining super-resolution and machine learning permits…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/milesim-combining-super-resolution-and-machine-learning-permits-high-throughput-virus-structure-analysis22 Jul 2024: Search site. Laser Analytics Group. MiLeSIM: combining super-resolution and machine learning permits high-throughput virus structure analysis. MiLeSIM: combining super-resolution and machine learning permits high-throughput virus structure analysis, -
Flat-Field Super-Resolution Localization Microscopy with a Low-Cost…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/flat-field-super-resolution-localization-microscopy-with-a-low-cost-refractive-beam-shaping-element22 Jul 2024: Search site. Laser Analytics Group. Flat-Field Super-Resolution Localization Microscopy with a Low-Cost Refractive Beam-Shaping Element. Rowlands CJ, Ströhl F, Ramirez PPV, Scherer KM & Kaminski CF. "Flat-Field Super-Resolution Localization -
Single Molecule Translation Imaging Visualizes the Dynamics of Local…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/single-molecule-translation-imaging-visualizes-the-dynamics-of-local-b-actin-synthesis-in-retinal-axons22 Jul 2024: Search site. Laser Analytics Group. Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons. Ströhl F, Lin JQ, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF, "Single Molecule -
Measurement of flame surface density for turbulent premixed flames…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/measurement-of-flame-surface-density-for-turbulent-premixed-flames-using-plif-and-dns22 Jul 2024: Search site. Laser Analytics Group. Measurement of flame surface density for turbulent premixed flames using PLIF and DNS. Hult, J; Gashi, S; Chakraborty, N; Klein, M; Jenkins, KW; Cant, S; Kaminski, CF, "Measurement of flame surface density for -
A Highly Porous Metal-Organic Framework System to Deliver Payloads…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/a-highly-porous-metal-organic-framework-system-to-deliver-payloads-for-gene-knockdown22 Jul 2024: Search site. Laser Analytics Group. A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown. Teplensky MH, Fantham M, Poudel C, Hockings C, Lu M, Guna A, et al. A Highly Porous Metal-Organic Framework System to Deliver -
Analyzing receptor assemblies in the cell membrane using fluorescence …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/analyzing-receptor-assemblies-in-the-cell-membrane-using-fluorescence-anisotropy-imaging-with-tirf-microscopy22 Jul 2024: Search site. Laser Analytics Group. Analyzing receptor assemblies in the cell membrane using fluorescence anisotropy imaging with TIRF microscopy. Analyzing receptor assemblies in the cell membrane using fluorescence anisotropy imaging with TIRF -
Temperature Response of an Acoustically Forced Turbulent Lean…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/temperature-response-of-an-acoustically-forced-turbulent-lean-premixed-flame-a-quantitative-experimental-determination22 Jul 2024: We also critically review the limitations of CARS used in our experiments, pertaining to spatial resolution and associated biasing further downstream from the bluff-body. -
Structural progression of amyloid- Arctic mutant aggregation in cells …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/pdf-structural-progression-of-amyloid-arctic-mutant-aggregation-in-cells-revealed-by-multiparametric-imaging22 Jul 2024: Our findings uncover the structural basis of the progression of Arctic mutant Aβ42 aggregation in the cell. -
Absolute concentration measurements of C 2 in a diamond CVD reactor…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/absolute-concentration-measurements-of-c-2-in-a-diamond-cvd-reactor-by-laser-induced-fluorescence22 Jul 2024: Search site. Laser Analytics Group. Absolute concentration measurements of C 2 in a diamond CVD reactor by laser-induced fluorescence. Kaminski, C; Ewart, P, "Absolute concentration measurements of C2 in a diamond CVD reactor by laser-induced -
Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/direct-observation-of-heterogeneous-amyloid-fibril-growth-kinetics-via-two-color-super-resolution-microscopy22 Jul 2024: Our technique offers new capabilities in the study of amyloid growth dynamics at the molecular level and is readily translated to the study of the self-assembly of other nanostructures. -
A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo | …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/a-fret-sensor-for-non-invasive-imaging-of-amyloid-formation-in-vivo-122 Jul 2024: We describe here, however, a Fçrster resonance energy transfer sensor that permits the aggregation kinetics of amyloidogenic proteins to be quantified in living systems by exploiting our observation that amyloid assemblies ... Our study confirms the -
Thermometry of an oxy-acetylene flame using multiplex degenerate…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/thermometry-of-an-oxy-acetylene-flame-using-multiplex-degenerate-four-wave-mixing-of-c-222 Jul 2024: Search site. Laser Analytics Group. Thermometry of an oxy-acetylene flame using multiplex degenerate four-wave mixing of C-2. Kaminski, CF; Hughes, IG; Lloyd, GM; Ewart, P, "Thermometry of an oxy-acetylene flame using multiplex degenerate four-wave -
First Person Bioimage: An Online Tool for Presentation and…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/first-person-bioimage-an-online-tool-for-presentation-and-publication-of-volumetric-data22 Jul 2024: Search site. Laser Analytics Group. First Person Bioimage: An Online Tool for Presentation and Publication of Volumetric Data. Fantham M, Kaminski CF, "First Person Bioimage: An Online Tool for Presentation and Publication of Volumetric Data", -
Curvature and wrinkling of premixed flame kernels comparisons of OH…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/curvature-and-wrinkling-of-premixed-flame-kernels-comparisons-of-oh-plif-and-dns-data22 Jul 2024: Search site. Laser Analytics Group. Curvature and wrinkling of premixed flame kernels comparisons of OH PLIF and DNS data. Gashi, S; Hult, J; Jenkins, KW; Chakraborty, N; Cant, S; Kaminski, CF, "Curvature and wrinkling of premixed flame kernels - -
The metathetic degradation of polyisoprene and polybutadiene in block …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/the-metathetic-degradation-of-polyisoprene-and-polybutadiene-in-block-copolymers-using-grubbs-second-generation-catalyst22 Jul 2024: Search site. Laser Analytics Group. The metathetic degradation of polyisoprene and polybutadiene in block copolymers using Grubbs second generation catalyst. Sedransk KL, Kaminski CF, Hutchings LR, and Moggridge GD, "The metathetic degradation of -
Spectroscopic use of a novel blue diode laser in a wavelength region…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/spectroscopic-use-of-a-novel-blue-diode-laser-in-a-wavelength-region-around-450-nm22 Jul 2024: Search site. Laser Analytics Group. Spectroscopic use of a novel blue diode laser in a wavelength region around 450 nm. Burns IS, Hult J, Kaminski CF (2004) "Spectroscopic use of a novel blue diode laser in a wavelength region around 450 nm" Applied -
Evanescent wave broadband cavity enhanced absorption spectroscopy…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/evanescent-wave-broadband-cavity-enhanced-absorption-spectroscopy-using-supercontinuum-radiation-a-new-probe-of-electrochemical-processes22 Jul 2024: Search site. Laser Analytics Group. Evanescent wave broadband cavity enhanced absorption spectroscopy using supercontinuum radiation: A new probe of electrochemical processes. M. Schnippering, P.R. Unwin, J. Hult, T. Laurila, C.F. Kaminski, J.M. -
High repetition-rate wavelength tuning of an extended cavity diode…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/high-repetition-rate-wavelength-tuning-of-an-extended-cavity-diode-laser-for-gas-phase-sensing22 Jul 2024: Search site. Laser Analytics Group. High repetition-rate wavelength tuning of an extended cavity diode laser for gas phase sensing. Hult, J; Burns, IS; Kaminski, CF, "High repetition-rate wavelength tuning of an extended cavity diode laser for gas -
Highly potent soluble amyloid-β seeds in human Alzheimer brain but…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/highly-potent-soluble-amyloid-b-seeds-in-human-alzheimer-brain-but-not-cerebrospinal-fluid22 Jul 2024: Search site. Laser Analytics Group. Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid. Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid, Fritschi S K, Langer F, -
Nanoscopic insights into seeding mechanisms and toxicity of…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/nanoscopic-insights-into-seeding-mechanisms-and-toxicity-of-a-synuclein-species-in-neurons22 Jul 2024: Search site. Laser Analytics Group. Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons. Pinotsi D, Michel CH, Buell AK, Laine RF, Mahou P, Dobson CM, Kaminski CF, Kaminski Schierle GS, "Nanoscopic insights -
Lifetime imaging of a fluorescent protein sensor tracks ER thiol…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/lifetime-imaging-of-a-fluorescent-protein-sensor-tracks-er-thiol-redox-revealing-its-surprising-stability22 Jul 2024: Search site. Laser Analytics Group. Lifetime imaging of a fluorescent protein sensor tracks ER thiol redox revealing its surprising stability. Avezov E, Cross BCS, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, Ron D, "Lifetime -
The HCCI Combustion Process in a Single Cycle – High-Speed Fuel…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/the-hcci-combustion-process-in-a-single-cycle-2013-high-speed-fuel-tracer-lif-and-chemiluminescence-imaging22 Jul 2024: Search site. Laser Analytics Group. The HCCI Combustion Process in a Single Cycle – High-Speed Fuel Tracer LIF and Chemiluminescence Imaging. Hultqvist, A; Christensen, M; Johansson, B; Richter, M; Nygren, J; Hult, J; Alden, M, "The HCCI -
Catalytic and chaperone-like functions in an intrinsically disordered …
https://laser.ceb.cam.ac.uk/publications/publication-summaries/catalytic-and-chaperone-like-functions-in-an-intrinsically-disordered-protein-associated-with-desiccation-tolerance22 Jul 2024: Enzymes usually require precise three-dimensional positioning of residues at the active site, but our results suggest this need not be the case.
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