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doi:10.1016/j.molcel.2008.05.027
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsK%20MolCell%202008%20Lowe.pdf16 Aug 2008: In. the overlapping regions, Watson-Crick base pairs form be-. tween the different strands, though the DNA used is blunt-. -
Photographs - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/photographs/21 Jul 2023: Photographs The LMB has an extensive collection of photographs and images, a selection of which can be viewed here by either browsing the collection or -
doi:10.1016/j.neuron.2005.05.004
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Jockusch_Neuron2005.pdf17 Jun 2005: Neuron 17, 1241–1249. Miele, A.E., Watson, P.J., Evans, P.R., Traub, L.M., and Owen, D.J.(2004). -
DNA 60th Anniversary celebrated at Cambridge - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdna-60th-anniversary-celebrated-at-cambridge%2F&format=xml25th April 1953, Francis Crick and Jim Watson published their groundbreaking paper in Nature, in which they revealed to the world the double. -
LMB Nobel Facts - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/achievements/lmb-nobel-prizes/nobel-facts/21 Jul 2023: 1962 - Francis Crick & Jim Watson (Physiology or Medicine). 1958 - Fred Sanger (Chemistry). ... In 1962, the LMB was awarded 2 separate Nobel Prizes: Francis Crick and Jim Watson (Physiology or Medicine), and Max Perutz and John Kendrew (Chemistry). -
Tyrosine Residues in Phospholipase C�2 Essential for the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11606584.pdf20 Apr 2002: Tyrosine Residues in Phospholipase C2 Essential for the EnzymeFunction in B-cell Signaling. Received for publication, August 8, 2001, and in revised form, October 9, 2001Published, JBC Papers in Press, October 17, 2001, DOI 10.1074/jbc.M107577200. -
PII: S1097-2765(03)00356-3
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/gripdomain.pdf27 Oct 2003: genes. Proc. Natl. Acad. Sci. USA90, 8952–8956.Analytical UltracentrifugationCollins, B.M., Watson, P.J., and Owen, D.J. -
Interactive Tools forCryo-EM Map Fitting Paul EmsleyMRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-June-PSI.pdf19 Jun 2018: Base-stacking restraints:(parallel plane restraints). LIBG Restraints. (Watson Crick and) Wobble, Reverse Wobble. -
Evolving nature of the AP2 a-appendage hubduring clathrin-coated…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004.pdf23 Nov 2004: Evolving nature of the AP2 a-appendage hubduring clathrin-coated vesicle endocytosis. Gerrit JK Praefcke1,2, Marijn GJ Ford1,Eva M Schmid, Lene E Olesen,Jennifer L Gallop, Sew-Yeu Peak-Chew,Yvonne Vallis, M Madan Babu,Ian G Mills3 and Harvey T -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Aug-Stockholm.pdf15 Aug 2018: Base-stacking restraints:(parallel plane restraints). LIBG Restraints. (Watson Crick and) Wobble, Reverse Wobble. -
Supplemental Materials Supp MethodsSupp Fig. 1 Sequence conservation…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004Sup.pdf23 Nov 2004: J Biol Chem278, 46772-46781. Miele, A. E., Watson, P. J., Evans, P. -
“The LMB provides an unsurpassed environment for both new ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=1885218 Jan 2021: Francis Crick and James Watson, 1962 - discovery of the structure of DNA. -
Expression, purifica0on, characteriza0on, and crystalliza0on So how…
https://www2.mrc-lmb.cam.ac.uk/download/03-protein-expression-crystallization-and-mutagenesis-meindert-lamers/?wpdmdl=18793&refresh=6649f7ad76e8c17161235652 May 2013: Watson & Crick). Recommended reading: Liga0on Independent Cloning Aslanidis C, de Jong PJ. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/32
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/32 -
Scientific Models - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/scientific-models/21 Jul 2023: Base plate from the Watson and Crick 1953 model. Signed by Francis Crick and Jim Watson. ... A year later I was able to get Jim Watson’s signature when he stopped by the LMB on a visit.’ Arthur Arnone, 28 October 2003. -
Functional Depletion of Mahogunin by Cytosolically Exposed Prion…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/59_Chakrabarti_O_Cell_2009.pdf13 Jun 2009: Functional Depletion of Mahoguninby Cytosolically Exposed Prion ProteinContributes to NeurodegenerationOishee Chakrabarti1 and Ramanujan S. Hegde1,1Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, -
coot-user-manual.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot-user-manual.pdf28 Sep 2012: 16311.85.2 watson-crick-pair. 16411.85.3 watson-crick-pair-for-residue-range. 164. xix. 11.86 Sequence (Assignment). 16411.86.1 print-sequence-chain. -
Publications
https://www2.mrc-lmb.cam.ac.uk/groups/jes/publications.html17 Sep 2020: Ho, T.L.F., Guilbaud, G., Blow, J.J., Sale, J.E. and Watson, C.J. -
New method to untangle the contribution of signalling pathways…
https://www2.mrc-lmb.cam.ac.uk/new-method-to-untangle-the-contribution-of-signalling-pathways-involved-in-asymmetric-cell-division/28 Sep 2023: In this study, co-led by Joseph Watson and Lara Krüger, the team developed an assay which allows the contribution of each pathway involved in the process to be dissected. ... Watson, JL., Krüger, LK., Ben-Sasson, AJ., Bittleston, A., Shahbazi, M., -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x77.html24 Aug 2021: watson_crick_pair() : c-interface.h. ... watson_crick_pair_for_residue_range() : c-interface.h. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1985
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1985 -
Browse the photo archive - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/photographs/browse-all/31 Mar 2021: Reproduction of Watson & Crick DNA Model. -
Recordings - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/recordings/21 Jul 2023: Isaac Asimov introduces James Watson and Francis Crick in the story of the structure of DNA, 8 July 1974. ... Discovering the double helix. James Watson talks about the discovery of the double helix in a lecture at Cold Spring Harbor Laboratory, November -
Kiyoshi Nagai (1949 - 2019) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/kiyoshi-nagai-1949-2019/2 Oct 2019: In this last complex, the detailed description of non-Watson-Crick base pairs between the 3’ splice site AG dinucleotide and both the branch-point adenosine and the 5’ splice site -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/download/twinningaandaotherapathologiesa-andreyalebedeva-a/?wpdmdl=18788&refresh=6649f7ae1dfb7171612356611 Jun 2013: a. b. Human macrophage receptor CLEC5A for dengue virus Watson, A. -
Expression, purifica0on, characteriza0on, and crystalliza0on So how…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_crystallography_course_2013/lectures/20130430_Cryst_course.pdf2 May 2013: Watson & Crick). Recommended reading: Liga0on Independent Cloning Aslanidis C, de Jong PJ. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/20969
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/20969{"id":20969,"date":"2021-08-06T16:48:14","date_gmt":"2021-08-06T14:48:08","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=20969"},"modified":"2021-11-18T14:33:20","modified_gmt":"2021-11-18T14:33:20","slug":"herbert-freddie-gutfreund","st -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1968
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1968{"id":1968,"date":"2012-07-18T15:55:14","date_gmt":"2012-07-18T14:55:03","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=1968"},"modified":"2021-05-21T13:29:26","modified_gmt":"2021-05-21T12:29:26","slug":"lmb-alumni-carl-ivar-br -
Books - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/books/21 Jul 2023: DNA. The Big Idea: Crick, Watson & DNA. Strathern, Paul. London: Arrow Books, 1997. ... The involvement of RNA in the synthesis of nucleic acids’ by James Watson. -
History of the LMB - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/history-of-the-lmb/21 Jul 2023: Nobel Prize for Physiology or Medicine: Francis Crick and Jim Watson. -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_crystallography_course_2013/lectures/pathologies_and_twinning.pdf11 Jun 2013: a. b. Human macrophage receptor CLEC5A for dengue virus Watson, A. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/21995
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/21995{"id":21995,"date":"2022-01-05T11:54:57","date_gmt":"2022-01-05T11:54:21","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=21995"},"modified":"2022-01-05T12:18:56","modified_gmt":"2022-01-05T12:18:56","slug":"donald-caspar-1927-2021","stat -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/26
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/26{"id":26,"date":"2012-06-25T09:58:08","date_gmt":"2012-06-25T09:58:08","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=26"},"modified":"2023-07-21T12:49:27","modified_gmt":"2023-07-21T11:49:27","slug":"photographs","status":"publ -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/28892
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/28892{"id":28892,"date":"2022-12-15T10:50:17","date_gmt":"2022-12-15T10:50:17","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=28892"},"modified":"2022-12-15T10:51:51","modified_gmt":"2022-12-15T10:51:51","slug":"lmb-through-the-years-60-years-of-me -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/997
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/997{"id":997,"date":"2012-07-03T09:13:21","date_gmt":"2012-07-03T09:13:21","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=997"},"modified":"2023-07-21T12:49:21","modified_gmt":"2023-07-21T11:49:21","slug":"fast-facts","status":"pub -
Site Map - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/site-map/21 Feb 2020: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Site Map. -
LMB Alumni List - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/9 May 2024: LMB Alumni List This is an alphabetical listing of past members of the LMB, complete with tenure dates. The list has been compiled by cross-referencing -
Michael Fuller (1936 - 2019) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/michael-fuller-1936-2019/28 Nov 2019: This was especially apt, as Michael was already working in the Laboratory when Francis Crick and James Watson announced the structure of DNA and unveiled their model, in 1953. -
1982 - Aaron Klug - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/achievements/lmb-nobel-prizes/1982-aaron-klug/21 Jul 2023: 1982 Chemistry Prize - Aaron Klug “for his development of crystallographic electron microscopy and his structural elucidation of biologically important -
1980 - Fred Sanger - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/achievements/lmb-nobel-prizes/1980-fred-sanger/21 Jul 2023: 1980 Chemistry Prize - Fred Sanger “for their contributions concerning the determination of base sequences in nucleic acids” -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1018
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1018{"id":1018,"date":"2012-07-03T09:31:54","date_gmt":"2012-07-03T09:31:54","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=1018"},"modified":"2023-07-21T12:49:56","modified_gmt":"2023-07-21T11:49:56","slug":"published-research","st -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/14
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/14{"id":14,"date":"2012-06-25T09:56:10","date_gmt":"2012-06-25T09:56:10","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=14"},"modified":"2023-07-21T12:49:24","modified_gmt":"2023-07-21T11:49:24","slug":"history-of-the-lmb","status -
1997 - John Walker - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/achievements/lmb-nobel-prizes/1997-john-walker/21 Jul 2023: 1997 Chemistry Prize - John Walker “for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP)” -
1958 - Fred Sanger - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/achievements/lmb-nobel-prizes/1958-fred-sanger/21 Jul 2023: 1958 Chemistry Prize - Fred Sanger “for his work on the structure of proteins, especially that of insulin” -
2017 - Richard Henderson - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/achievements/lmb-nobel-prizes/2017-richard-henderson/21 Jul 2023: 2017 Chemistry Prize - Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in -
Coot Scripting Interface: c-interface.h File Reference
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface_8h.html24 Aug 2021: Coot Scripting Interface 7000. c-interface.h File Reference. Coot Scripting Interface - General. Functions. SCM . merge_molecules (SCM add_molecules, int imol). merge molecules More.. cis_peptides (int imol). return cis_peptide info for imol. -
Moments of Genius: Nobel laureate Venki Ramakrishnan describes how…
https://www2.mrc-lmb.cam.ac.uk/moments-of-genius-nobel-laureate-venki-ramakrishnan-describes-how-james-watson-discovered-dna-base-pairing/6 Dec 2010: Search this website. Moments of Genius: Nobel laureate Venki Ramakrishnan describes how James Watson discovered DNA base pairing. ... Moments of Genius: Nobel laureate Venki Ramakrishnan describes how James Watson discovered DNA base pairing. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/28
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/28Isaac Asimov introduces James Watson and Francis Crick in the story of the structure of DNA, 8 July 1974. ... content/uploads/james_watson-33x50.jpg 33w" sizes="(max-width: 130px) 100vw, 130px" //pnulnliDiscovering the double helix. -
Blue Sky Collaboration - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/research/blue-sky-collaboration/10 Jan 2024: Stangherlin, A., Watson, J.L., Wong, D.C.S., Barbiero, S., Zeng, A., Seinkmane, E., Peak Chew, S., Beale, A.D., Hayter, E.A., Guna, A., Inglis, A.J., Putker, M., -
Francis Crick (1916 - 2004) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/francis-crick-1916-2004/30 Mar 2021: He will be best remembered for DNA, whose structure he discovered with Jim Watson in 1953.
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