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30 Apr 2024: Motor behaviour and cognitive tests will place the mice shortly in an unfamiliar environment. ... To assess motor behaviour, we will perform tests such as Catwalk, Rotarod, and Grip strength and to assess cognitive behaviour, we will perform Barnes maze

30 Apr 2024: Hence, although individual elements of CVD can be modelled in a 'test tube' (e.g. ... Thus, when we use animal models this will be because we typically have several years worth of 'test tube' experiments that support the use of animal experiments for

30 Apr 2024: The cost of mental health disorders to the UK in terms of social, economic and health factors is extremely high. ... As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals.

30 Apr 2024: As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals. ... We perform these manipulations to test the impact of early life stress on the behaviour of the offspring as adults.

30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 4 of 8. scientific tests have been developed for it which we could make use of to investigate in our study. ... Potential refinements include increased monitoring if test animals show earlier clinical signs or weight

30 Apr 2024: neurophysiological basis of visual cognition and memory will have far reaching social and economic implications. ... This test is important to allow animals to be directed into studies that they are most appropriate for.

30 Apr 2024: of cognitive and emotional symptoms of neuropsychiatric disorders will have far reaching social and economic implications. ... can move freely once in the test apparatus and (iii) are tested for less than 40 minutes.

30 Apr 2024: This project aims to improve our understanding of the cellular mechanisms that underlie ischaemia-reperfusion injury (tissue damage caused when blood supply returns to tissue) and test the safety and effectiveness ... This project will generate academic

30 Apr 2024: The exact set of behavioural tests will be used is dependent on the mouse model being investigated. ... Our assessment includes both non-regulated and regulated tests, most having no noticeable adverse effects.

30 Apr 2024: We expect to uncover a pathway to promote myelin regeneration, and test its therapeutic potential. ... tests, or labelling (with dyes or fluorescent markers) the central nervous system under non recovery anaesthesia.

30 Apr 2024: This will help reduce the vast burden of pregnancy-induced origins of cardiovascular disease, thereby having a major clinical, economic, and societal impact on cardiovascular health. ... It may be possible in future to extend some of the work by using

29 Apr 2024: Each of our experiments is designed on the back of a robust statistical approach that relies on state-of-the-art statistical tests and models. ... covariance, and associated post-hoc tests, dimensional analyses, such as multiple and factorial regressions,

30 Apr 2024: We will also study how the test agent distributes itself around the body. ... Dosing will usually be daily, but this may vary depending upon the test agent.

30 Apr 2024: The inclusion of further detail to support why specific tests are most appropriate for the science. ... Further detail required in the Animal Experience section. • The inclusion of a timeline to show when the tests will be performed and at what stage

29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines.

30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans.

30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in

29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients.

30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes.

29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to

30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function.

30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease.

30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary.

30 Apr 2024: These tests showed that the devices work well in recording nerve activity and helping to control how nerves work. ... For example, we do a lot of computer simulations, which helps us test fewer things in living animals.

30 Apr 2024: The knowledge gained will be used to develop and test of novel therapeutic interventions. ... Live animals are required to test in vivo therapies. Wherever possible, animals will be killed prior to tissue harvest.

29 Apr 2024: 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals per test group at each time point).

30 Apr 2024: This licence will enable us to test new treatments in mice and rats and predict how much to use in these models. ... Pharmacokinetic studies are usually not hypothesis testing in a statistical sense, so we do not test for a significant difference in

30 Apr 2024: The majority of the data will be collected at the end of studies, where animals will be under deep terminal anaesthesia, in order to perform tests on how effective a test ... Giving a drug before injury can test its effect on bleeding and clot formation.

29 Apr 2024: This project will develop and test the safety and effectiveness of new vaccines against EHV induced disease. ... We typically use 7 animals per vaccine group, and we envisage we will test at least 2 candidate vaccines.

29 Apr 2024: What's the aim of this project? The aim of this project is to study how the immune system recognises cancer cells, and test the safety and effectiveness of drugs that ... The proposed project will allow a better understanding of how the immune system

30 Apr 2024: Typically such tests will be performed whilst agents that modify gut hormone release or act on gut hormone receptors are also administered, typically directly into the blood stream or into the ... Metabolic fitness test like these will typically involve

30 Apr 2024: Many of these behavioural tests will monitor the impact of pain on spontaneous behaviours, e.g. ... We also use non-interventional behavioural tests to measure the impact of pain conditions on an animal’s behaviour.

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... body, as well as monitoring how the test agent performs in an intact biological system.

30 Apr 2024: Typically, a mouse will experience each of these above procedures. Some animals will undergo 1, 2 or sometimes 3 behavioural tests typically to test motor skills, anxiety and spatial navigation. ... 3. Methods (test substances, quarantine and monitoring,

30 Apr 2024: Why were they not suitable? It is not possible to entirely replace animal experiments for this project since it is important to test whether the principles identified in cell culture are

30 Apr 2024: This will allow us to change the signalling within particular cells and test the consequences on the mechanics and development of the whole organ. ... Why were they not suitable? It is not possible to entirely replace animal experiments for this project

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and

30 Apr 2024: This work will make extensive use of pilot studies, as most of the test substances will be by definition novel, as they concern novel technologies or modalities (method of treatment). ... Pilot or tolerability studies will be carried out for new models

29 Apr 2024: A small subset of mice will undergo a blood test to check how much of a certain marker of interest they have (for example, a protein). ... The best, non-invasive way to monitor disease progression is to test the urine for protein.

30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects.

29 Apr 2024: This will contribute to a reduction in the burden of developmental origins of heart disease, thereby having a positive clinical, economic and societal impact on health. ... The real ethical, biological and economic value of the avian relative to other

29 Apr 2024: We primarily use adult female mice, hamsters and guinea pigs to test our vaccines. ... There exists no cell-based model or less sentient model to test vaccines.

30 Apr 2024: rodent models to test how well they remain detectable and/or functional over a defined period of time. ... The information gathered here will inform us which drug is best suited to take forward to test in the target animal species.

30 Apr 2024: endoscopy, bronchoscopy, MRI/CT/PET) and non imaging techniques (e.g. blood tests and functional assays).

30 Apr 2024: licence. Furthermore, when possible, we will generate primary cell lines from mouse brains which will allow us to test some of our hypotheses in vitro prior to performing elaborate experiments that ... 1) We will perform pilot studies and in vitro tests

30 Apr 2024: This will create new opportunities to test new therapies that can stop inflammation, brain damage, and the subsequent development of neuropsychiatric disorders in the offspring. ... This has allowed us to test whether treatments will be (1) safe for

30 Apr 2024: After this she may undergo a glucose tolerance test (as described in point 5) prior to her being humanely killed and her tissues collected and stored for laboratory analyses. ... c) Glucose or insulin tolerance tests which require injection of either

30 Apr 2024: We also want to test whether subcutaneous implants can be used to accurately monitor body temperature in the mice.

29 Apr 2024: We aim to test the use of the mouse grimace scale for each protocol (https://nc3rs.org.uk/grimacescales).