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30 Apr 2024: Motor behaviour and cognitive tests will place the mice shortly in an unfamiliar environment. ... To assess motor behaviour, we will perform tests such as Catwalk, Rotarod, and Grip strength and to assess cognitive behaviour, we will perform Barnes maze

30 Apr 2024: Hence, although individual elements of CVD can be modelled in a 'test tube' (e.g. ... Thus, when we use animal models this will be because we typically have several years worth of 'test tube' experiments that support the use of animal experiments for

30 Apr 2024: The cost of mental health disorders to the UK in terms of social, economic and health factors is extremely high. ... As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals.

30 Apr 2024: As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals. ... We perform these manipulations to test the impact of early life stress on the behaviour of the offspring as adults.

30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 4 of 8. scientific tests have been developed for it which we could make use of to investigate in our study. ... Potential refinements include increased monitoring if test animals show earlier clinical signs or weight

30 Apr 2024: neurophysiological basis of visual cognition and memory will have far reaching social and economic implications. ... This test is important to allow animals to be directed into studies that they are most appropriate for.

30 Apr 2024: of cognitive and emotional symptoms of neuropsychiatric disorders will have far reaching social and economic implications. ... can move freely once in the test apparatus and (iii) are tested for less than 40 minutes.

30 Apr 2024: This project aims to improve our understanding of the cellular mechanisms that underlie ischaemia-reperfusion injury (tissue damage caused when blood supply returns to tissue) and test the safety and effectiveness ... This project will generate academic

30 Apr 2024: The exact set of behavioural tests will be used is dependent on the mouse model being investigated. ... Our assessment includes both non-regulated and regulated tests, most having no noticeable adverse effects.

30 Apr 2024: We expect to uncover a pathway to promote myelin regeneration, and test its therapeutic potential. ... tests, or labelling (with dyes or fluorescent markers) the central nervous system under non recovery anaesthesia.

30 Apr 2024: This will help reduce the vast burden of pregnancy-induced origins of cardiovascular disease, thereby having a major clinical, economic, and societal impact on cardiovascular health. ... It may be possible in future to extend some of the work by using

29 Apr 2024: Each of our experiments is designed on the back of a robust statistical approach that relies on state-of-the-art statistical tests and models. ... covariance, and associated post-hoc tests, dimensional analyses, such as multiple and factorial regressions,

30 Apr 2024: We will also study how the test agent distributes itself around the body. ... Dosing will usually be daily, but this may vary depending upon the test agent.

25 Apr 2024: 3. Establishment Licence Holder Report/Update. Forced swim test has now been removed from use in the UK. ... We received a PETA Freedom of Information request this week around forced swim tests, and we were able to tell them we don’t have any project

30 Apr 2024: The inclusion of further detail to support why specific tests are most appropriate for the science. ... Further detail required in the Animal Experience section. • The inclusion of a timeline to show when the tests will be performed and at what stage

25 Apr 2024: had their PAT test this week. will have theirs next week.

25 Apr 2024: The PAT test is ongoing. 8. Training and Competencies It has been noticed that some people are still performing Schedule 1 that have not completed module 6.3.

29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines.

30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans.

30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in