Search

15 Sep 2003: Thus, this isthe most stringent test of specicity. The effect ofthe ligand-binding domain of PPAR on the ATPaseactivity of Hsp90 is shown in Figure 3(c). ... This perhaps reects thehigher basal ATPase activity of yeast Hsp90. Perhaps the most stringent

11 Sep 2003: Review R81. How do small single-domain proteins fold?Sophie E Jackson. Many small, monomeric proteins fold with simpletwo-state kinetics and show wide variation in foldingrates, from microseconds to seconds. Thus, stableintermediates are not a

15 Sep 2003: Fersht et al. (1994) have proposed akinetic test to distinguish between these possibili-ties. ... This test is based on Brùnsted behaviourobserved in physical organic chemistry for simplesystems in which a single bond is made/broken inthe transition

16 Sep 2003: and Fersht, A.R.: Structure of the Hydrophobic Core in the Trans-ition State for Folding of Chymotrypsin Inhibitor 2: A Critical Test of the Protein EngineeringMethod of Analysis.

15 Sep 2003: test whether such an unstable intermediatestate is present on the folding pathway ofFKBP12, refolding experiments were performedin the presence of 0.4 M Na2SO4.